Clues to the Cause of Male Pattern Baldness

March 2012 in “ Nature ”

Melissa Lee Phillips

male pattern baldness lipid compound hair growth biological mechanisms hair loss lipids hair growth regulation baldness

TLDR Targeting a specific lipid could help treat male pattern baldness.

The document discussed a lipid compound that was found to suppress hair growth in both mice and men, suggesting a potential target for treating male pattern baldness. This research provided insights into the biological mechanisms underlying hair loss, indicating that targeting this lipid compound could offer a new approach to managing or reversing baldness. The study highlighted the importance of understanding the role of lipids in hair growth regulation, which could lead to the development of effective treatments for male pattern baldness.

View this study on nature.com →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

205 citations, March 2012 in “Science Translational Medicine”

PGD2 stops hair growth and is higher in bald men with AGA.

Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

research Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

235 citations, January 2011 in “Journal of Clinical Investigation”

Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.

research Influence of Prostaglandin F2α and Its Analogues on Hair Regrowth and Follicular Melanogenesis in a Murine Model

103 citations, April 2005 in “Experimental dermatology”

Prostaglandin F2alpha and related compounds can increase hair growth and darken hair in mice.

research Prostaglandin-Induced Hair Growth

162 citations, August 2002 in “Survey of Ophthalmology”

Latanoprost can make eyelashes longer, thicker, and darker.

Related Community Posts Join

6 / 1000+ results

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 8 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 479 upvotes 11 months ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community We all regret not acting on hair loss sooner. What is something else we can prevent if we act now?

in Chat 94 upvotes 1 year ago

The conversation discusses the importance of early action in various aspects of life such as healthy eating, skincare, fitness, sleep, financial planning, and career development to prevent future health issues, regret, and financial hardship. Specific treatments mentioned include using sunscreen and tretinoin for anti-aging skincare.

community It’s crazy how it’s 2018 and the only hair loss treatments we have feature undesirable side effects and/or aren’t even effective for many people.

136 upvotes 6 years ago

Hair loss treatments, including minoxidil, dermarolling, finasteride, dutasteride, hair transplants, hair systems, and shaving the head. The conversation covers various opinions on these treatments and mentions possible side effects as well as alternatives like wigs, vitamins, and lifestyle changes. The post expresses disappointment that there has been no major breakthrough in the field of hair loss treatments despite decades of research.

community Finasteride, also known as Propecia or Proscar, treats male pattern baldness and enlarged prostate in millions of men worldwide. But a new study suggests the drug may also provide a surprising and life-saving benefit: lowering cholesterol and cutting the overall risk of cardiovascular disease.

in Research/Science 531 upvotes 1 year ago

The conversation discusses the potential benefits of finasteride (Fin) for lowering cholesterol and reducing cardiovascular disease risk, with users sharing personal experiences and opinions on the medication's effects on health and hair loss. Some users report positive changes in cholesterol levels after taking finasteride, while others are skeptical or joke about its effects.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 58 upvotes 7 months ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

Similar Research

5 / 1000+ results

research Clues About The Causes Of Male Pattern Baldness

June 2012 in “Nature digest”

A substance called prostaglandin D2 is linked to stopping hair growth in men with common baldness.

research The Modulatable Stem Cell Niche: Tissue Interactions During Hair and Feather Follicle Regeneration

66 citations, July 2015 in “Journal of Molecular Biology”

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

research Potential Factors Contributing to Androgenetic Alopecia

8 citations, January 1996 in “Springer eBooks”

Male pattern baldness may be caused by factors like poor blood circulation, scalp tension, stress, and hormonal imbalances, but the exact causes are still unclear.

research Proceedings of the Ninth World Congress for Hair Research 2015

January 2017 in “Journal of Investigative Dermatology Symposium Proceedings”

The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.

research Androgen Effects in Mammals

7 citations, January 2003 in “Elsevier eBooks”

Testosterone is crucial for development, growth, and various body functions in mammals.