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The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Essential oils in cosmetics can offer benefits but may cause allergies and should be used carefully.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

Cystatin M/E strongly inhibits cathepsin V and cathepsin L, important for skin formation.

MDP hydrogel heals wounds faster and better than other treatments in diabetic mice.

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

Jasmonic acid and its derivatives play important roles in plant health and have potential uses in medicine and agriculture.

Mushrooms have beneficial properties for skin and hair care products and have great potential for future cosmetic use.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

Shampoos are designed to clean and improve hair and scalp health, with specific ingredients for different hair types and conditions.

Photothermal hydrogels are promising for infection control and tissue repair, and combining them with other treatments could improve results and lower costs.

Certain drugs that block specific enzymes can help treat prostate diseases.

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

RU 58841 may treat acne, hair loss, and excessive hair growth.

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

Plant steroid hormones show growth, health, and medicinal benefits in various organisms, including potential for treating diseases.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

*Acorus calamus* has many medicinal benefits but needs more safety research.

Mitoxantrone is effective for treating acute leukemia, especially in older patients, with a lower risk of heart damage.

Germacrone from Curcuma aeruginosa may help treat conditions related to male hormones by blocking a specific enzyme.

Some plants may help with hair growth and have fewer side effects than synthetic drugs, but more research is needed to confirm their effectiveness.

Certain diets can affect skin conditions, but more research is needed to understand these relationships fully.

New sensor detects minoxidil accurately and effectively.

Some congenital hair disorders improve in childhood or with treatments like minoxidil and retinoids, while others like Netherton syndrome and trichothiodystrophy have a poor prognosis.

Some Middle Eastern plants may help treat diabetes and could be alternatives to current drugs, but more research is needed.

Oral retinoids are effective for treating severe skin disorders but have reversible side effects and risks for pregnant women.