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Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).

Higher androgen levels and site-specific AR expression cause sex-related skeletal differences, and certain steroids can boost AR expression and androgen effects in bone cells.

AR gene not major factor in female hair loss; different from male hair loss.

The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

Male yak hair growth is influenced by DHT synthesis, which is promoted by 5α-red1 and AR during growth phases, while E2 may inhibit growth through ERα.

AI and AR are improving cosmetic dermatology but face challenges like data quality and ethical concerns.

Higher levels of heat shock protein 27 and lower levels of miR-1 can increase AR levels, leading to hair loss in men.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

Blocking testosterone speeds up wound healing in males.

Essential oils from Curcuma species, like turmeric, have compounds that can fight inflammation, cancer, and bacteria, and can also stimulate hair regrowth in bald males.

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

Androgens can help prevent memory problems caused by apoE4.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.

Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.

Insufficient androgen action in male fetuses can cause genital development issues due to genetic mutations or environmental chemicals.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

Oral retinoids are effective for severe skin conditions but require careful use due to side effects.

Mouse genital development depends on male or female hormones for specific features.

A gene called HDAC9 might be a new factor in male-pattern baldness.

Exemestane may protect bones by stimulating osteoblast growth through androgen-related pathways.

Low androgen levels might delay prostate cancer but could lead to more aggressive, therapy-resistant cancers.

The study suggests that motor neurons created from stem cells of patients with spinal and bulbar muscular atrophy show signs of the disease, including changes in protein levels and cell functions.

Androgenetic alopecia linked to COVID-19 severity; drugs reducing androgen receptor activation may help.

Genes play a significant role in male-pattern baldness, and understanding them could lead to new treatments and insights into related health issues.