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The document concludes that permanent hair loss conditions are complex, require early specific treatments, and "secondary permanent alopecias" might be a more accurate term than "secondary cicatricial alopecia."

UK medical students lack dermatology education, liver biopsy patients with risk factors show more fibrosis, and certain fungi resist drugs due to melanin; genetics may influence female hair loss.

Some chemicals can permanently or temporarily remove color from skin and hair, which can be distressing and is not well-regulated in cosmetics.

Atopic dermatitis may have genetic causes and can be treated with pharmacologic methods, glycerin creams, and controlling Staphylococcus aureus colonization.

A new mutation in the ST14 gene broadens the understanding of ichthyosis-hypotrichosis syndrome.

A 15-year-old girl with no menstrual period was diagnosed with a genetic condition that makes her body unable to respond to male hormones, leading to female characteristics despite having male genetic makeup.

SARMs may be an effective treatment for a certain type of breast cancer by blocking cancer growth and spread.

A genetic mutation caused severe rickets and alopecia in an Indian patient, but high-dose calcium and phosphate treatment improved their condition.

Dupilumab helped improve skin and prevent new lesions in a child with a rare immune disorder and severe eczema.

Genetic changes in mice help understand skin and hair disorders, aiding treatment development for acne and hair loss.

KAP9.2 and Hoxc13 genes are important for cashmere growth and vary in activity during different stages.

A small change in the TRPS1 gene leads to a less severe form of a syndrome affecting hair, nose, and finger development.

Finasteride in male rats causes liver and metabolic issues in their offspring.

Sex hormones, especially androgens, play a key role in causing acne.

The protein FLCN is involved in cellular cleanup and is regulated by ULK1.

VDR regulation varies by tissue and is crucial for its biological functions.

Lower SMAD2/3 activation predicts more severe skin cancer.

Two siblings with a genetic mutation had a form of rickets that doesn't respond to vitamin D.

Extracellular vesicles, including exosomes from certain cells, can stimulate hair growth.

A TP63 gene mutation causes significant hair loss and mild skin, nail, and tooth abnormalities.

Autism's genetics are linked with early age of puberty and less hair loss, but not with hormone levels or polycystic ovary syndrome.

Tissue environment greatly affects the unique epigenetic makeup of regulatory T cells, which could impact autoimmune disease treatment.

CRISPR/Cas9 has improved precision and control but still faces clinical challenges.

The document concludes that understanding tissue degeneration is crucial for diagnosing skin lesions.

Mitochondrial Complex I reduces inflammation and increases bone breakdown by affecting certain immune cells.

Inactive stem cells in hair follicles and muscles can avoid detection by the immune system.

Dlx3 is essential for hair growth and regeneration.