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    Glossary Apoptosis

    natural process where cells intentionally die for organism health

    Apoptosis, also known as programmed cell death, is a natural process by which cells intentionally die to help maintain the health and balance of an organism. This process is crucial for development, immune function, and removing damaged or potentially harmful cells. In the context of hair, apoptosis can influence hair follicle cycling and contribute to conditions like alopecia if dysregulated.

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    1. Apoptosis in human skin development: Morphogenesis, periderm, and stem cells Developmental dynamics · 1994 · 253 citations
    2. Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis Archives of Toxicology · 2018 · 215 citations
    3. Apoptosis and keratin intermediate filaments Cell Death and Differentiation · 2002 · 180 citations
    4. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007 · 171 citations
    5. Analysis of Apoptotic Cell Death in Human Hair Follicles In Vivo andIn Vitro Journal of Investigative Dermatology · 1998 · 140 citations
    6. Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis Carcinogenesis · 2003 · 138 citations
    7. Do Hair Bulb Melanocytes Undergo Apotosis During Hair Follicle Regression (Catagen)? 1998 · 130 citations
    8. Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression American Journal of Pathology · 2006 · 128 citations
    9. <i>Sept4/</i> ARTS Regulates Stem Cell Apoptosis and Skin Regeneration Science · 2013 · 78 citations
    10. Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity Acta dermato-venereologica · 2017 · 66 citations
    11. Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation EMBO journal · 2003 · 65 citations
    12. Apoptosis and cutaneous biology Journal of The American Academy of Dermatology · 1997 · 60 citations
    13. Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2006 · 58 citations
    14. Expression of vascular endothelial growth factor, apoptosis inhibitors (survivin and p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical study British Journal of Dermatology · 2004 · 58 citations
    15. Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege Journal of Investigative Dermatology · 2013 · 53 citations
    16. Hydroxyl radical mediates cisplatin-induced apoptosis in human hair follicle dermal papilla cells and keratinocytes through Bcl-2-dependent mechanism APOPTOSIS · 2011 · 52 citations
    17. Adipose-derived stem cells alleviate radiation-induced dermatitis by suppressing apoptosis and downregulating cathepsin F expression Stem Cell Research & Therapy · 2021 · 50 citations
    18. Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia ˜The œAmerican journal of pathology · 2000 · 47 citations
    19. Melatonin promotes secondary hair follicle development of early postnatal cashmere goat and improves cashmere quantity and quality by enhancing antioxidant capacity and suppressing apoptosis Journal of Pineal Research · 2019 · 46 citations
    20. Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro European Journal of Cell Biology · 2010 · 42 citations
    21. Apoptosis resistance in peripheral blood lymphocytes of alopecia areata patients Journal of Autoimmunity · 2004 · 38 citations
    22. Topical ALA-Photodynamic Therapy for Acne Can Induce Apoptosis of Sebocytes and Down-regulate Their TLR-2 and TLR-4 Expression Annals of Dermatology · 2011 · 37 citations
    23. Long-term Oral Administration of 5α-reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats Urology · 2013 · 34 citations
    24. <i>In vivo </i>CD44‐CD49d complex formation in autoimmune disease has consequences on T cell activation and apoptosis resistance European Journal of Immunology · 2006 · 33 citations
    25. Apoptosis in follicles of individuals with female pattern hair loss is associated with perifollicular microinflammation International Journal of Cosmetic Science · 2016 · 30 citations
    26. Trypsin-induced follicular papilla apoptosis results in delayed hair growth and pigmentation Developmental Dynamics · 1997 · 29 citations
    27. PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis Stem Cell Research & Therapy · 2019 · 26 citations
    28. Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration Developmental Cell · 2021 · 25 citations
    29. Effects of Short-Term Finasteride on Apoptotic Factors and Androgen Receptors in Prostate Cancer Cells The Journal of Urology · 2008 · 25 citations
    30. p75 Neurotrophin Receptor Antagonist Retards Apoptosis-driven Hair Follicle Involution (Catagen) Journal of Investigative Dermatology · 2003 · 24 citations