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    Glossary Antiandrogenic

    substances inhibit male sex hormones like testosterone

    Antiandrogenic refers to substances or treatments that inhibit the effects of androgens, which are male sex hormones like testosterone. These substances can be used to treat conditions like androgenic alopecia (hair loss) and prostate cancer by blocking the action of these hormones, thereby reducing their influence on hair follicles and other tissues.

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    1. Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships Current Medicinal Chemistry · 2000 · 204 citations
    2. Pharmacology of antiandrogens Journal of Steroid Biochemistry · 1986 · 97 citations
    3. The Antiandrogenic Action of 4–Androsten–3–one–17β– Carboxylic Acid and Its Methyl Ester on Hamster Flank Organ1 Endocrinology · 1973 · 87 citations
    4. Spironolactone is an Effective and Well Tolerated Systemic Antiandrogen Therapy for Hirsute Women* The Journal of Clinical Endocrinology & Metabolism · 1989 · 78 citations
    5. Antiandrogenic Therapy With Finasteride Attenuates Cardiac Hypertrophy and Left Ventricular Dysfunction Circulation · 2015 · 56 citations
    6. The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells Nature Communications · 2021 · 50 citations
    7. Mixed “Antiandrogenic” Chemicals at Low Individual Doses Produce Reproductive Tract Malformations in the Male Rat Toxicological sciences · 2018 · 49 citations
    8. Androgens and Antiandrogens Annals of the New York Academy of Sciences · 2003 · 41 citations
    9. Evaluation of the rodent Hershberger assay using three reference endocrine disrupters (androgen and antiandrogens) Reproductive Toxicology · 2003 · 37 citations
    10. Spironolactone: An Anti-androgenic and Anti-hypertensive Drug That May Provide Protection Against the Novel Coronavirus (SARS-CoV-2) Induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19 Frontiers in Medicine · 2020 · 36 citations
    11. Epitestosterone—an endogenous antiandrogen? 1989 · 35 citations
    12. Evaluation of 5α-reductase inhibitory activity of certain herbs useful as antiandrogens Andrologia · 2013 · 33 citations
    13. The Development and Evaluation of An Ovulation Inhibitor (Diane®) Containing An Antiandrogen Acta obstetricia et gynecologica Scandinavica · 1979 · 33 citations
    14. ANTIANDROGEN THERAPY IN DERMATOLOGY International Journal of Dermatology · 1996 · 32 citations
    15. A systematic review of antiandrogens and feminization in transgender women Clinical endocrinology · 2020 · 31 citations
    16. Clinical applications of antiandrogens Journal of Steroid Biochemistry · 1988 · 29 citations
    17. Comparing the risk of adverse pregnancy outcomes of Chinese patients with polycystic ovary syndrome with and without antiandrogenic pretreatment Fertility and Sterility · 2018 · 27 citations
    18. The effect of the antiandrogen IIα-hydroxyprogesterone on sebum production and cholesterol concentration of sebum British Journal of Dermatology · 1982 · 27 citations
    19. Topical Minoxidil Does Not Act as an Antiandrogen in the Flank Organ of the Golden Syrian Hamster Archives of Dermatology · 1987 · 26 citations
    20. Antiandrogen Therapy for Skin and Hair Disease Dermatologic Clinics · 2006 · 20 citations
    21. Multiple readout assay for hormonal (androgenic and antiandrogenic) and cytotoxic activity of plant and fungal extracts based on differential prostate cancer cell line behavior Journal of Ethnopharmacology · 2014 · 19 citations
    22. 5α-Reductase Inhibitory Components as Antiandrogens From Herbal Medicine Journal of acupuncture and meridian studies · 2010 · 19 citations
    23. Solubilities of Flutamide, Dutasteride, and Finasteride as Antiandrogenic Agents, in Supercritical Carbon Dioxide: Measurement and Correlation Journal of Chemical & Engineering Data · 2009 · 19 citations
    24. Antiandrogenic progestins for treatment of signs of androgenisation and hormonal contraception 2004 · 17 citations
    25. Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite The Journal of Steroid Biochemistry and Molecular Biology · 1994 · 16 citations
    26. Antiandrogenic activities of<i>Glycyrrhiza glabra</i>in male rats International Journal of Andrology · 2009 · 15 citations
    27. Screening of synthetic and natural product databases: Identification of novel androgens and antiandrogens European journal of medicinal chemistry · 2014 · 14 citations
    28. Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens Journal of Medicinal Chemistry · 1995 · 12 citations
    29. Topical Antiandrogens Archives of Dermatology · 1985 · 11 citations
    30. Other Antiandrogens Dermatology · 1998 · 11 citations