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This study identified procyanidin B2 and leucopelargonidin from Saraca asoca as potential inhibitors in PCOS by showing high binding energy scores against key enzymes involved in estrogen and testosterone biosynthesis.

In this retrospective chart review, researchers observed that estrogen monotherapy effectively suppressed testosterone levels below 50ng/dL in all transfeminine patients studied, particularly those using injectable formulations, though the small sample size and ongoing data collection limit these findings.

In this retrospective study, among transfeminine patients aged 19-81 receiving gender-affirming estrogen therapy, 100% achieved testosterone suppression without anti-androgens when serum estradiol exceeded 100pg/mL, predominantly using injectable estrogen.

This study found that bilateral orchiectomy allows most transgender women to stop anti-androgen medications, with 91.7% discontinuing them post-surgery and 25% reducing estrogen use.

This review discusses treatment options for hirsutism in women of childbearing age, focusing on the use of contraceptives, CPA, spironolactone, and third-line therapies, and reports no clinical results.

This article discusses the potential mechanism by which 5α-reductase inhibitors might offer protection against SARS-CoV-2, emphasizing possible roles of dehydroepiandrosterone and its impact on nitric oxide bioavailability, but reports no new experimental results.

In this study, researchers explored whether minoxidil, a common treatment for androgenetic alopecia, may have estrogenic activity and found preliminary evidence suggesting it could act as a partial agonist of Estrogen Receptor α (ERα).

This study found that blocking androgen receptors in male rats during the perinatal period led to permanently increased estrogen and ER-a expression in the hypothalamus, affecting sexual preference in adulthood.

This study found that cyproterone acetate with ethynyl estradiol improved acne and seborrhea within 3–6 months in women, but had less satisfactory results for alopecia and hirsutism.

This review discusses the role of antiandrogenic gestagens in treating androgen-dependent skin disorders and highlights the need for dermatologists to collaborate with endocrinologists and gynecologists for effective management.

In this study, O. forskahlii seed oil was found to promote hair growth in rats and exhibit anti-aging effects on human skin cells by enhancing fibroblast proliferation and inhibiting inflammation and enzyme activity, indicating potential for cosmetic use.

This study observed that chemically-induced intersex frogs displayed altered brain mRNA profiles, with finasteride increasing certain hormone-related gene expressions and fadrozole reducing aromatase activity without affecting gene transcript levels.

This study identified Aquilaria sinensis and Piper cubeba as tropical plants with potential anti-androgenic and anti-estrogenic properties that could help prevent or alleviate benign prostatic hyperplasia and prostate cancer.

This study examines the pathogenetic role of hormonal imbalances in chronic prostatitis, highlighting that decreased androgens and increased estrogens contribute to prostate inflammation and impaired spermatogenesis, and explores hormonal therapies' potential for restoring reproductive function.

This case report describes a 22-year-old woman who developed persistent, non-scarring hair loss and premature ovarian failure following a myeloablative umbilical cord transplant for acute myeloid leukemia.

This review discusses hormone-related hair disorders and explores potential therapies, including microparticle-based drug delivery systems, without providing new clinical findings.

This review discusses the roles of androgens and estrogens in skin functions and disorders, and highlights the use of estrogen-progestin treatments and anti-androgens in managing hirsutism and acne, without reporting new results.

This review concluded that oral finasteride for men and topical minoxidil for both genders have the most evidence supporting their effectiveness and safety for treating androgenetic alopecia.

This article reviews the potential of combining antiandrogenic and antiestrogenic treatments for BPH, highlighting aromatase inhibitors, but presents no new clinical results; further research is needed.

In this report, five female patients undergoing hormonal anticancer therapy for breast cancer prevention developed pattern alopecia, which the authors attribute to androgen-estrogen imbalance caused by antiestrogenic drugs.

This review discusses the creation of transgender-specific guidelines by WPATH and the Endocrine Society, based mostly on clinical experience, and reports no new results.

This review discusses factors affecting hair aging and the current pharmacological treatments for androgenetic alopecia, mentioning topical minoxidil and oral finasteride, but does not present new clinical findings.

This review discusses the effects of cross-sex hormone treatments on metabolic functions in transgender individuals and reports no new clinical results; it highlights potential insights into the role of sex steroids in diseases like cardiovascular disease and diabetes.

In this study, gender-affirming hormonal treatment was associated with increased hair growth, acne, and alopecia prevalence in transgender individuals assigned female at birth, while opposite dermatological changes were observed in those assigned male at birth.

This study describes the enzymatic processes through which DHEA is converted to active sex steroids in human skin, highlighting an androgenic effect on sebaceous glands and estrogenic effects in the vagina.

New treatments for male hypogonadism are effective and should be personalized.

This study found that prenatal exposure to certain pesticides may lead to earlier breast development in girls, potentially associated with higher androgen levels.

This study found that women experiencing diffuse hair loss had significantly lower levels of plasma sex-hormone binding globulin compared to controls, while their testosterone levels remained normal.

This case report describes total alopecia in a 53-year-old woman after 13 months of tamoxifen treatment for breast cancer, with normal hair distribution maintained elsewhere.

Saw palmetto extract can block the enzyme that converts testosterone in pig prostate cells.