Hormonal Imbalance as a Factor in the Development of Chronic Prostatitis: Mechanisms and Therapy Prospects
November 2025
in “
Репродуктивное здоровье Восточная Европа
”
Studysummary This study examines the pathogenetic role of hormonal imbalances in chronic prostatitis, highlighting that decreased androgens and increased estrogens contribute to prostate inflammation and impaired spermatogenesis, and explores hormonal therapies' potential for restoring reproductive function.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The article explores the role of hormonal imbalance in chronic prostatitis (CP) and its effects on male reproductive health, highlighting the roles of testosterone, estrogens, and prolactin. It finds that low androgen levels and increased estrogen contribute to prostate inflammation and hyperplasia, as well as spermatogenesis disruption. Hyperprolactinemia is linked to reduced pituitary function, decreased libido, and poorer ejaculate quality. The article reviews current research on hormonal therapy's effectiveness for CP and reproductive issues, discussing the potential of androgens, anti-estrogens, 5-alpha reductase inhibitors, and dopamine receptor agonists. It stresses the need for further clinical trials to evaluate long-term combination therapy efficacy and develop personalized treatments.
