Hormonal Imbalance as a Factor in the Development of Chronic Prostatitis: Mechanisms and Therapy Prospects

    November 2025 in “ Репродуктивное здоровье Восточная Европа ”
    Е.А. Семенова, Р.И. Хисамиева, Я.С. Кудрявцева, Д.В. Данилова, А.А. Кагало
    TLDR Hormonal imbalance contributes to chronic prostatitis and affects male reproductive health.
    The article explores the role of hormonal imbalance in chronic prostatitis (CP) and its effects on male reproductive health, highlighting the roles of testosterone, estrogens, and prolactin. It finds that low androgen levels and increased estrogen contribute to prostate inflammation and hyperplasia, as well as spermatogenesis disruption. Hyperprolactinemia is linked to reduced pituitary function, decreased libido, and poorer ejaculate quality. The article reviews current research on hormonal therapy's effectiveness for CP and reproductive issues, discussing the potential of androgens, anti-estrogens, 5-alpha reductase inhibitors, and dopamine receptor agonists. It stresses the need for further clinical trials to evaluate long-term combination therapy efficacy and develop personalized treatments.
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