Clinical Effectiveness of Bilateral Orchiectomy in Reducing Anti-Androgens in Transgender Females

April 2020

Ross G. Everett, Kaylee M. Luck, Bryce A. Toburen, Jay I. Sandlow

bilateral orchiectomy anti-androgens gender dysphoria androgen reducing medication exogenous estrogen supplementation BO anti-androgen therapy estrogen supplementation

TLDR Bilateral Orchiectomy effectively reduces the need for anti-androgen medication in most transgender females.

The study conducted between 2008-2018 assessed the impact of Bilateral Orchiectomy (BO) on the hormone regimen of 19 patients with gender dysphoria. The median age at the time of surgery was 46 years. All 16 patients for whom pre-operative medication regimen information was available were on anti-androgen therapy prior to surgery for a median duration of 42.5 months. Post-operatively, 91.7% of patients stopped anti-androgen therapy, and 25% reduced their exogenous estrogen supplementation. The study concluded that BO is an effective means of negating the need for ongoing androgen reducing medication for the majority of transgender female patients.

View this study on auajournals.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 6 results

community 2 months of topical minoxidil (5%) use and there is a shadow now!

in Transgender 192 upvotes 10 months ago

The post discusses the user's experience with topical minoxidil (5%) for hair loss, showing some improvement after 2 months. Suggestions from others include keeping the hair shorter on the sides and back, adding finasteride for better results, and considering a shaved head look, though the latter was debated for its femininity.

community Amplifica’s AMP-303 Study Unveils New Hope for Hair Loss Treatments

in Treatment 33 upvotes 4 days ago

AMP-303, a new injectable treatment for androgenetic alopecia, showed promising results in increasing hair count and density with minimal side effects. The treatment demonstrated significant hair regrowth and durability, offering new hope for those with hair loss.

community The theory that explains everything. The malloclusion theory has been proven.

in Research/Science 27 upvotes 1 year ago

Brian Dye's theory links skeletal malocclusion type II to hair loss, suggesting it's a blood flow issue. Treatments mentioned include minoxidil, finasteride, and anti-inflammatory drugs like benaxoprofen.

community topical fluridil/eucapil + dut to block all DHT+T from scalp?

in Treatment 6 upvotes 2 years ago

User experienced slow gains with topical fin+min, switched to topical dut+min, and considered adding Eucapil. Another user suggested DUT may be less effective topically due to high molar mass and mentioned Fluridil as a weak anti-androgen that could help.

community Dermatologist tells me I don't have any serious signs of hair loss. This is my hairline.

in Chat 30 upvotes 9 months ago

A user is confused about a dermatologist's positive assessment of their scalp despite concerns about their hairline. They discuss using oral minoxidil, concerns about side effects from finasteride, and difficulty finding topical finasteride.

community Anyone else growing tired of the finasteride wars?

in Finasteride/Dutasteride 169 upvotes 10 months ago

The conversation is about differing experiences with finasteride for hair loss, with some users reporting side effects and others not, and the debate over the drug's safety and effectiveness. Specific treatments mentioned include finasteride, dutasteride, and topical finasteride.

Related Research

1 / 1 results

research Clinical Effectiveness of Bilateral Orchiectomy in Reducing Anti-Androgens in Transgender Females

April 2020

Bilateral Orchiectomy effectively reduces the need for anti-androgen medication in most transgender females.