52 citations
,
October 2012 in “Journal of Dermatological Science” This review presents updated tables of mouse mutants with hair growth abnormalities to aid in understanding the molecular mechanisms of human hair disorders, but reports no new clinical results.
52 citations
,
May 2003 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that overexpression of parathyroid hormone-related protein in mice resulted in 30–40% shorter hair due to premature transition into the catagen phase of the hair cycle.
51 citations
,
January 2004 in “Domestic animal endocrinology” This study concluded that an endogenous circannual rhythm of prolactin secretion in mouflon influences their seasonal hair growth and moulting cycle, which varies under different photoperiodic and melatonin treatments.
51 citations
,
January 2003 in “Hormone Research in Paediatrics” This review discusses hormonal influences on hair growth and suggests that understanding hormone-gene interactions may improve treatment of hirsutism and alopecia, but reports no new clinical findings.
47 citations
,
May 1999 in “Reproduction” This study found that temperature affects the influence of daylength on prolactin secretion and hair growth in dairy goats, without significant involvement of melatonin.
46 citations
,
March 2019 in “Journal of Pineal Research” The study found that melatonin treatment in early postnatal cashmere goats increased both the quantity and quality of cashmere by promoting secondary hair follicle development and enhancing antioxidant enzyme activities.
44 citations
,
July 2011 in “Dermato-endocrinology” This article reviews the skin condition myxedema associated with hypothyroidism, highlighting its characteristic non-pitting, glycosaminoglycan-rich nature, and reports no new results.
42 citations
,
September 2015 in “Gene” This study demonstrated that FGF5s acts as an inhibitor of FGF5 in regulating hair growth cycles in cashmere goat dermal papilla cells.
40 citations
,
January 2016 in “PLoS ONE” The study found that exposing Arbas Cashmere goats to a short photoperiod significantly increased cashmere production by extending the anagen phase of hair follicles, with gene expression changes identified as contributing factors.
40 citations
,
June 2013 in “Scientific Reports” This study found an association between a splice site variant in the KRT71 gene and curly hair in Selkirk Rex cats, identifying a significant locus on chromosome B4.
36 citations
,
January 2021 in “Scientific Reports” This study identified key genes and signaling pathways involved in the growth phases of Pashmina goat hair follicles, highlighting the role of several gene families and transcription factors in fiber quality and growth regulation.
35 citations
,
April 2014 in “Journal of proteomics” In this study, experimentally induced weight loss in merino sheep led to a decrease in wool fiber diameter and increased expression of certain high sulfur and glycine-tyrosine proteins, potentially impacting wool quality and industry preferences.
31 citations
,
May 2008 in “Drug Discovery Today: Disease Mechanisms” This review discusses the physiology of hair follicles, their disorders, and the principles behind developing treatments, reporting no new results.
30 citations
,
October 2012 in “Current Opinion in Endocrinology, Diabetes and Obesity” This review discusses the effects of thyroid hormone on the skin and explores the potential for using it to treat skin diseases, but reports no new clinical results.
30 citations
,
June 2006 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, oral zinc sulphate was found to cause hair hypopigmentation and significantly inhibit eumelanogenesis in mice.
29 citations
,
September 2012 in “Dermatologic Clinics” This article reviews the causal mechanisms of hair follicle disorders, focusing on inflammation, genetics, environment, and hormones, but it reports no new clinical results.
28 citations
,
January 2013 in “Journal of Thyroid Research” This review discusses the potential therapeutic use of thyroid hormones on skin conditions, highlighting the need for further research but reporting no new experimental results.
27 citations
,
January 2020 in “Experimental Dermatology” This review discusses the role of immune cells in mammalian hair cycle control and highlights their potential relevance to human hair cycling disorders, reporting no new clinical findings.
27 citations
,
February 2017 in “Clinical, Cosmetic and Investigational Dermatology” In this study, a topical formulation with compounds from the monoterpenoid family significantly improved hair growth indicators like anagen:telogen ratio, hair fall, and visual hair density in men and women with pattern hair loss.
27 citations
,
January 2010 in “Animal” In these studies, researchers found that Peruvian camelids reach mature skin follicle development early, with specific cuticular characteristics useful for distinguishing fleece types, while Bolivian llamas have a mature follicle apparatus present at birth.
25 citations
,
February 2019 in “Genomics” This study reports that milk goats exhibit significantly more differentially expressed genes related to hair follicle cycling across different months compared to cashmere goats, especially in December.
24 citations
,
July 2011 in “PubMed” This review discusses the classic skin characteristics of hypothyroidism, notably generalized myxedema caused by increased glycosaminoglycan deposition, and reports no clinical results.
23 citations
,
May 2020 in “Cell Death and Disease” This study generated FGF5-knockout Dorper sheep using the CRISPR/Cas9 system, resulting in significantly increased fine-wool and active hair-follicle density, and explored downstream signaling pathways for potential applications in androgen alopecia treatment.
23 citations
,
March 1989 in “The Veterinary clinics of North America. Food animal practice” This review discusses dermatological issues in llamas, detailing common findings, parasites, and disorders, but reports no new clinical results; it highlights the need for recognizing normal skin variations and discusses potential treatments like zinc therapy for certain conditions.
22 citations
,
April 2015 in “Current problems in dermatology” Human hair follicles have a unique metabolism that changes between growth stages and may contribute to baldness.
19 citations
,
August 2019 in “Expert Opinion on Therapeutic Targets” This review discusses emerging targets for developing drugs to treat hair loss and reports no new clinical results; the authors emphasize the potential for therapies that regenerate hair follicles.
16 citations
,
September 2018 in “Journal of Ethnopharmacology” This review discusses the role of inheritance, androgens, and microinflammation in androgenetic alopecia and suggests some plant-based folk remedies may help address these factors but reports no new clinical results.
16 citations
,
December 2006 in “Expert Review of Dermatology” This review discusses the multifaceted roles of hair follicles in skin health, including potential contributions to skin neoplasias, and reports no new results.
15 citations
,
February 2021 in “Scientific Reports” This study found that novel RNA aptamers specifically inhibited FGF5-induced cell proliferation, suggesting their potential as candidates for treating FGF5-related diseases or hair disorders.
14 citations
,
August 2016 in “Journal of nanomedicine research” This animal study found that biscuits fortified with zinc oxide nanoparticles improved growth, appetite, and hair growth in zinc-deficient rats more effectively than traditional zinc forms, without apparent toxicity.