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Hormone therapy increases the risk of heart-related issues in transgender women and may affect heart health in transgender men.

Testosterone therapy improved physical and social health in a male with 49,XXXXY syndrome.

The over-the-counter supplement DHEA could make COVID-19 worse, especially in diabetics and people with G6PD deficiency.

Hormone therapy improves mental well-being in transgender individuals but requires ongoing health monitoring.

Hormone therapy is safe and effective for transgender adults, but requires regular monitoring and mental health support.

Hirsutism is mainly caused by high androgen levels or sensitivity, with PCOS being the most common cause.

Gender-affirming hormone therapy improves physical performance in trans men to the level of cisgender men, while in trans women, it increases fat mass and decreases muscle mass, with no advantage in physical performance after 2 years.

Testosterone replacement is recommended for men with low testosterone levels and symptoms of hypogonadism.

The document says that hair loss in women is often due to androgenic alopecia, similar to male baldness, and that hirsutism is treated with hormonal and cosmetic methods.

Hirsutism is excessive male-pattern hair growth in women, often caused by hormonal imbalances, and requires ongoing treatment to manage.

Menopause affects hair and skin; more research needed for treatment.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

Antiandrogens can treat female hormonal conditions, but environmental ones may harm reproductive health.

Many women experience sexual dysfunction, but few seek help, and better treatment and medical training are needed.

Testosterone supplements can increase muscle mass and strength in older men with low levels, but long-term effects and risks need more research.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

DHEA did not improve sexual function, well-being, or menopausal symptoms in postmenopausal women with low libido but caused side effects like acne and increased facial hair.

Exercise improves insulin sensitivity and hormone regulation in PCOS rats.

Testosterone implants in women require pharmacological dosing to be effective and are generally safe and well-tolerated.

The document suggests various treatments for PCOS, including medication for menstrual issues, insulin resistance, and excess hair, as well as fertility treatments, while highlighting the need for personalized care and lifestyle changes.

Transdermal testosterone can improve sexual desire in postmenopausal women but lacks long-term safety data and is not FDA-approved for this use.

Severe male balding may increase the risk of serious COVID-19, and treatments that reduce androgens or block a specific enzyme might help protect these individuals.

Clascoterone may be a promising treatment for hair loss.

Diagnose and manage hair issues in women by checking medical conditions and using personalized treatments.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

The modified Ferriman-Gallwey method is a useful tool for diagnosing hirsutism.

The NAMS 2014 recommendations guide healthcare providers on treating health issues in midlife women, emphasizing individualized care and informed decision-making.

Use minoxidil for hair loss treatment; assess results after 6 months.