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Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

Testosterone therapy can modestly improve sexual function in menopausal women but should be used cautiously and is not recommended for routine measurement in sexual dysfunction or hirsutism.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Male pattern baldness is an unintended side effect of the body's use of androgens for muscle growth, especially in those genetically prone to it.

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

A boy with severe Vitamin D-resistant rickets did not respond to treatment and lacked a common symptom, suggesting a need for alternative treatments.

Hormone imbalances can cause specific skin changes, which may help in early detection of endocrine disorders.

Most adrenal cortex tumors are benign and non-secreting, but proper diagnosis and treatment are important due to the rare possibility of cancer.

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

Finasteride helps treat hair loss and prostate enlargement by blocking a specific enzyme.

Certain Chinese herbs, especially Cacumen platycladi, can promote hair regrowth and reduce hair loss-related hormone levels in mice.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

Some new progesterone derivatives are better at blocking testosterone conversion than a common drug.

Some women with acne have higher levels of free testosterone, which might suggest using hormonal treatments for acne.

Cyproterone acetate is effective for treating hirsutism and acne but less so for hair loss, with side effects similar to birth control pills.

IGF-1 affects hair loss and could be a potential treatment.

The document concludes that Rabson-Mendenhall syndrome requires novel treatments for insulin resistance and emphasizes the importance of dental care in affected patients.

Prolactin may be important for skin growth and immune function.

Sebaceous glands in male pattern hair loss patients have more lobules and might cause early hair growth phase shifts.

The vitamin D receptor can work without its usual activating molecule.

Adenosine may promote hair growth by increasing FGF-7 levels in dermal papilla cells.

New hormonal contraceptives are safer, have fewer side effects, and offer health benefits for women.

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

Some lesser-known causes of PCOS include autoimmune issues, genetic mutations, and changes in the body's microbiome.

Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.

Higher SHBG levels are linked to less severe hair loss in women, but vitamin D levels don't seem to affect hair loss.

Ultrasound boosts finasteride's hair growth effects in mice.