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This research proposes to investigate the incidence of skin diseases in dogs from North-eastern India linked to deficiencies in alpha-linolenic and linoleic acids, as these essential fatty acids have anti-inflammatory and immunomodulatory benefits potentially aiding inflammatory skin disease therapy.

This study found that exosomes derived from human bone marrow mesenchymal stem cells significantly promote cutaneous wound healing in rats by modulating the TGF-β/Smad signaling pathway.

This study reported that transgenic mice with targeted TNF alpha expression in keratinocytes showed impaired weight gain, retarded hair growth, and skin changes, leading to cachexia and necrosis.

In this study, researchers found that intestine-derived human alpha defensin 5 enhances wound healing, reduces bacterial load, and promotes hair growth in murine burn wound beds by increasing LGR stem cell migration.

This study suggests that the absence of alpha5(IV)/alpha6(IV) chains in certain subepidermal basement membrane spots may relate to interactions with melanocytes in human skin.

This study found that α-MSH administration before skin wounding in adult mice reduced inflammation and scar area, suggesting a potential pathway to more regenerative healing.

This study found that two new progesterone derivatives showed higher antiandrogenic effects and 5α-reductase inhibition than finasteride in hamsters, particularly reducing seminal vesicle weight and flank organ size.

This study investigated the use of dissolving microneedle patches to improve the skin-lightening effects of alpha-arbutin and resveratrol, finding that the patches enhanced intradermal delivery and slightly decreased the melanin index without affecting skin hydration or causing irritation over 24 hours.

This study concluded that administering dutasteride for more than 8 weeks in rats could lead to irreversible erectile dysfunction, even after stopping the medication.

This study found that combining 5-alpha reductase inhibitors with alpha-blockers provided the best symptomatic relief and reduced the risk of clinical progression for BPH, while PDE5 inhibitors could offset sexual side effects.

This study found that finasteride significantly reduced dihydrotestosterone levels but did not provide clear evidence of impaired libido or erectile function compared to placebo in men.

This study reported that new drugs, despite lower specificity compared to certain immunobiological therapies, are effective across various challenging dermatological diseases, such as psoriasis, psoriatic arthritis, atopic dermatitis, alopecia areata, and vitiligo.

This study found that Alpha Lipoic Acid may help reduce cigarette smoke-induced skin damage in rats by improving collagen structure and reducing markers of oxidative stress.

This study found no positive association between the use of 5α-reductase inhibitors and the risk of male breast cancer.

The woman's skin and hair symptoms were confirmed as frontal fibrosing alopecia, and while facial papules are common in such cases, there's no effective local treatment, but systemic treatments can help.

This article presents a case of 5-alpha-reductase deficiency in a Saudi individual, reporting no new research findings.

This review discusses the potential of small extracellular vesicles (sEVs) as next-generation therapeutics, noting their ability to overcome biological barriers and modulate cellular environments for various diseases.

This study examined the dementia risk in patients with benign prostatic hyperplasia using alpha-blockers and 5-alpha reductase inhibitors, finding no significant association between these medications and increased dementia risk compared to no treatment, but noted higher risk probabilities for certain 5ARIs.

Smart microneedles using advanced tech could improve psoriasis treatment.

This consensus summary suggests that 5-alpha reductase inhibitors have clear benefits for benign prostatic hyperplasia, but their impact on prostate cancer prevention is still debated.

This review discusses the biochemical properties and clinical significance of 5 alpha-reductase isozymes and reports no new clinical results.

This research article focuses on nonsteroidal inhibitors of human type I steroid 5-alpha-reductase but reports no new results.

This article reviews the reported sexual and psychological side effects of 5-alpha reductase inhibitors for benign prostatic hyperplasia, emphasizing the need for further clinical studies.

This study found that 4 weeks of finasteride treatment significantly decreased DHT levels in bald scalp to levels similar to hair-containing scalp in men with male pattern baldness.

This review discusses the potential applications and challenges of small molecules in regenerative medicine, but it reports no new research findings.

This study found that disrupting Smad4 signaling in young mice led to overactivation of follicle stem cells, causing hyperplasia and depletion of the stem cell niche.

This review discusses the clinical and molecular history of 5-alpha reductase deficiency, highlighting its role in male sexual differentiation and potential therapeutic applications, but reports no new research outcomes.

This study concluded that five-alpha-reductase inhibitors may reduce prostate cancer risk but could increase the risk of high-grade prostate cancer in men regularly screened for the disease.

This study found that lowering serum DHT levels with 5 mg finasteride daily did not significantly alter serum gonadotropin levels in healthy young men after 28 days.

This study found that three months of oral finasteride treatment significantly decreased dihydrotestosterone levels and hair growth in hirsute women without negatively affecting gonadotropin secretion.