Persistent Erectile Dysfunction After Discontinuation of 5-Alpha Reductase Inhibitor Therapy in Rats Depending on the Duration of Treatment

    December 2018 in “ The World Journal of Men s Health ”
    Hyun Hwan Sung, Jiwoong Yu, Su Jeong Kang … Sung Won Lee
    Studysummary This study concluded that administering dutasteride for more than 8 weeks in rats could lead to irreversible erectile dysfunction, even after stopping the medication.
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    Research cited in this study 12

    1. Sexual Dysfunction in Subjects Treated with Inhibitors of 5α-Reductase for Benign Prostatic Hyperplasia: A Comprehensive Review and Meta-Analysis International Journal of Andrology · 2017
    2. Persistent Erectile Dysfunction in Men Exposed to 5α-Reductase Inhibitors, Finasteride, or Dutasteride PeerJ · 2017
    3. Finasteride, Not Tamsulosin, Increases Severity of Erectile Dysfunction and Decreases Testosterone Levels in Men With Benign Prostatic Hyperplasia Hormone Molecular Biology and Clinical Investigation · 2015
    4. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    5. Persistent Sexual and Nonsexual Adverse Effects of Finasteride in Younger Men Sexual medicine reviews · 2013
    6. Organic Causes of Erectile Dysfunction in Men Under 40 Urologia Internationalis · 2013
    7. Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology The Journal of Sexual Medicine · 2013
    8. Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
    9. Incomplete Recovery of Erectile Function in Rats After Discontinuation of Dual 5-Alpha Reductase Inhibitor Therapy The Journal of Sexual Medicine · 2012
    10. Effects of Oral Finasteride on Erectile Function in a Rat Model The Journal of Sexual Medicine · 2012
    11. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    12. The Effect of 5α-Reductase Inhibition With Dutasteride and Finasteride on Bone Mineral Density, Serum Lipoproteins, Hemoglobin, Prostate Specific Antigen, and Sexual Function in Healthy Young Men ˜The œJournal of urology/˜The œjournal of urology · 2008