Persistent Erectile Dysfunction After Discontinuation of 5-Alpha Reductase Inhibitor Therapy in Rats Depending on the Duration of Treatment

    December 2018 in “ The World Journal of Men s Health ”
    Hyun Hwan Sung, Jiwoong Yu, Su Jeong Kang, Mee Ree Chae, Insuk So, Jong Kwan Park, Sung Won Lee
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    TLDR Long-term use of dutasteride can cause permanent erectile dysfunction in rats.
    The study demonstrated that the duration of 5-alpha reductase inhibitor therapy, specifically with dutasteride, significantly affected the recovery from erectile dysfunction (ED) in rats. It was found that administering dutasteride for more than 8 weeks could lead to irreversible ED, even after the medication was discontinued. This suggested that prolonged use of such medication had lasting adverse effects on erectile function in the animal model.
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