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The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

Sex hormones affect brain injury differently in males and females.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

Dutasteride protects dopamine neurons in Parkinson's mice, but Finasteride doesn't.

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

Finasteride and dutasteride reduce neurosteroid production, possibly helping treat glioblastoma.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

The document concludes that Functional Hypothalamic Amenorrhea should be carefully diagnosed and managed to prevent health complications, using lifestyle changes and specific medications.

Testosterone significantly affects sexual desire in both men and women, but its impact on women is more complex and influenced by psychological factors.

Finasteride can cause lasting sexual dysfunction, depression, and other side effects, needing more research for treatment.

Finasteride can cause sexual dysfunction and depression, which may persist and require hormonal treatment.

Finasteride doesn't affect ovulation in normal women.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Excess androgens may cause PCOS, not just be a symptom.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Finasteride, a drug used for certain conditions, can cause serious side effects like sexual dysfunction, suicidal thoughts, and increased diabetes risk, and there's a need for more awareness and research about these effects.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Removing certain brain receptors in mice worsens seizure severity and response to treatment during hormone withdrawal.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

5-alpha-reductase inhibitors may help stabilize or slow down hair loss in some frontal fibrosing alopecia patients, but more research is needed to confirm their effectiveness and safety.

Stem cell therapy is promising for treating various health conditions, but more research is needed to understand its full potential and address challenges.

The true incidence of post-Finasteride syndrome is unclear, and more research is needed.

Omega-6 fats in certain cells boost male hormone production.

5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.

Dutasteride, usually used for prostate issues and hair loss, could potentially treat Amyotrophic Lateral Sclerosis (ALS) due to its neuroprotective, antioxidant, and anti-inflammatory properties, but more testing is needed.

Testosterone and its metabolites affect brain functions and could help treat neurological disorders.

5-alpha reductase inhibitors may help protect the brain and gut in Parkinson's disease.

Finasteride treatment in rats changed the expression of genes related to psychiatric and neurological functions, and these changes persisted after stopping the drug.