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    Glossary Alefacept

    biologic drug that targets T-cells in autoimmune conditions

    Alefacept is a biologic medication that was used to treat moderate to severe plaque psoriasis, an autoimmune skin condition. It works by targeting and reducing the activity of specific immune cells (T-cells) that are involved in the inflammatory process of psoriasis. Although it was effective for some patients, it has been discontinued in many markets due to the availability of newer treatments.

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      Treatment of Generalized Lichen Planus With Alefacept

      research Treatment of Generalized Lichen Planus With Alefacept

      52 citations , February 2006 in “Archives of Dermatology”
      This case report describes a 25-year-old woman with widespread lichen planus who did not respond to multiple systemic treatments, including antihistamines, hydroxychloroquine sulfate, and corticosteroids.

      research Alefacept for Severe Alopecia Areata

      43 citations , November 2009 in “Archives of dermatology”
      This study found that alefacept showed no significant improvement in treating severe alopecia areata compared to placebo over a 24-week period.
      Alefacept for Alopecia Areata

      research Alefacept for Alopecia Areata

      33 citations , December 2005 in “Archives of dermatology”
      This study presents case reports of four patients with alopecia areata or alopecia universalis, highlighting varied responses to treatments like prednisone, intralesional triamcinolone, and squaric acid dibutyl ester.
      Systemic Treatments for Alopecia Areata: A Systematic Review

      research Systemic treatments for alopecia areata: A systematic review

      41 citations , September 2018 in “Australasian journal of dermatology”
      This review suggests that oral prednisolone pulse therapy and oral inosiplex may be effective for alopecia areata, but robust evidence from randomized controlled trials is lacking, highlighting the need for better-designed future studies.
      Novel Therapies for Alopecia Areata: The Era of Rational Drug Development

      research Novel therapies for alopecia areata: The era of rational drug development

      9 citations , December 2017 in “The Journal of Allergy and Clinical Immunology”
      This review discusses the evolution of alopecia areata treatments towards more targeted therapies and reports no new clinical results, emphasizing cooperation between clinicians and scientists in understanding the disease's pathophysiology.
      Cytokine-Targeted Treatment in Alopecia Areata - New Possibilities?

      research Cytokine-targeted treatment in alopecia areata - new possibilities?

      1 citations , May 2023 in “Prospects in Pharmaceutical Sciences”
      This study reviews current treatments for alopecia areata, highlighting that despite various options like corticosteroids and immunosuppressives, their limited efficacy and potential side effects are challenges, while targeting specific cytokines has shown promise except with TNF inhibitors, which may worsen the condition.
      Dermatological Drugs, Topical Agents, And Cosmetics

      research Dermatological drugs, topical agents, and cosmetics

      1 citations , January 2005 in “Side effects of drugs annual”
      This chapter reviews various dermatological drugs and treatments, highlighting adverse effects, with no new clinical findings reported.
      Cancer

      research 12. Cancer

      July 2003 in “Journal of Cutaneous Medicine and Surgery”
      Some medications can improve skin conditions, while lifestyle factors like smoking and drinking may worsen them; treatments like monoclonal antibodies and imiquimod cream show promise for certain skin diseases.
      Pediatric Dermatology

      research 3. Pediatric Dermatology

      July 2003 in “Journal of Cutaneous Medicine and Surgery”
      Skin problems are common in Bangladesh due to arsenic, prompt treatment of diabetic foot ulcers is crucial, maternal transmission causes most neonatal herpes, treatments for pediatric vasculitis are effective, the chickenpox vaccine works, more frequent UVB therapy helps psoriasis, certain jobs increase hand dermatitis risk, monoclonal antibodies treat psoriasis well, lifestyle affects psoriasis, alefacept improves psoriasis, imiquimod cream partially clears basal cell carcinoma, and iron may not help chronic hair loss.
      Psoriasis, Acne, and Disorders of Keratinization

      research 11. Psoriasis/Acne and Disorders of Keratinization

      July 2003 in “Journal of Cutaneous Medicine and Surgery”
      Treating psoriasis with UVB light three times a week is faster than twice a week, and certain medications and lifestyle factors affect psoriasis treatment outcomes.
      HIV, Fungal, and Infectious Diseases

      research 5. HIV, Fungal and Infectious Diseases

      July 2003 in “Journal of Cutaneous Medicine and Surgery”
      The document concludes that various treatments for skin conditions are effective, but some require further research, and certain factors like gender and lifestyle can influence disease outcomes.
      Bullous/Mucous Membrane

      research 4. Bullous/Mucous Membrane

      July 2003 in “Journal of Cutaneous Medicine and Surgery”
      High blood pressure drugs often cause skin lupus, stopping the drug usually helps. A vaccine helps prevent genital herpes and HPV-16. More frequent light therapy clears psoriasis faster. No link was found between low iron and chronic hair loss.
      Obesity and the Skin: Skin Physiology and Skin Manifestations of Obesity

      research Obesity and the skin: Skin physiology and skin manifestations of obesity

      405 citations , May 2007 in “Journal of The American Academy of Dermatology”
      This review discusses the profound impact of obesity on skin physiology and dermatologic conditions and reports no new experimental results, recommending awareness and treatment strategy development for obesity-associated dermatoses.
      Alopecia Areata: A Review of Disease Pathogenesis

      research Alopecia areata: a review of disease pathogenesis

      191 citations , May 2018 in “British journal of dermatology/British journal of dermatology, Supplement”
      This study reviewed recent theories on alopecia areata's pathogenesis, highlighting its autoimmune nature due to immune privilege disruption in hair follicles, and noted current treatments have limited efficacy with high relapse rates, underscoring the need for further research into its mechanisms for better therapies.
      Low-Level Laser Therapy for Treatment of Hair Loss

      research Low‐level laser (light) therapy (LLLT) for treatment of hair loss

      165 citations , August 2013 in “Lasers in Surgery and Medicine”
      This review discusses the potential mechanisms and evidence supporting low-level laser therapy for stimulating hair growth in men and women, while noting its safety and effectiveness but needing further study on specific parameters.
      Interventions for Alopecia Areata

      research Interventions for alopecia areata

      164 citations , April 2008 in “Cochrane library”
      This review of interventions for alopecia areata found no significant treatment benefits for hair growth compared to placebo, indicating a need for larger, well-conducted studies.
      Lichen Planopilaris: Update on Diagnosis and Treatment

      research Lichen Planopilaris: Update on Diagnosis and Treatment

      160 citations , March 2009 in “Seminars in Cutaneous Medicine and Surgery”
      This article reviews lichen planopilaris, its presentation, and treatment challenges, and emphasizes the need for more research into its pathogenesis and therapy efficacy; it reports no new findings.
      Alopecia Areata: A Multifactorial Autoimmune Condition

      research Alopecia areata: A multifactorial autoimmune condition

      148 citations , December 2018 in “Journal of autoimmunity”
      This review discusses genetic and environmental factors contributing to autoimmunity in alopecia areata and reports no new clinical findings, emphasizing the need for further study on its aetiology and pathophysiology.
      Lupus Erythematosus: Systemic and Cutaneous Manifestations

      research Lupus erythematosus: systemic and cutaneous manifestations

      144 citations , September 2006 in “Clinics in Dermatology”
      This article outlines manifestations of systemic lupus erythematosus, noting rapid joint symptom improvement with corticosteroids and antimalarial drug responsiveness for skin symptoms, and links anti-Ro with photosensitive rash and subacute lupus.
      The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm

      research The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm

      77 citations , June 2017 in “Advances in Therapy”
      This review discusses recent advances and ongoing clinical trials in novel therapeutics for alopecia areata, despite the lack of current FDA-approved treatments for severe cases, and reports no new results.
      Alopecia Areata: An Evidence-Based Treatment Update

      research Alopecia Areata: An Evidence-Based Treatment Update

      72 citations , July 2014 in “American journal of clinical dermatology”
      This review analyzed randomized controlled trials on alopecia areata treatment and found that while several treatments showed effectiveness, most studies had limitations affecting their interpretability.
      Alopecia Areata: Evidence-Based Treatments

      research Alopecia Areata: Evidence-Based Treatments

      71 citations , March 2009 in “Seminars in cutaneous medicine and surgery”
      This review discusses evidence for alopecia areata treatments, highlighting their ability to stimulate hair growth but noting limited data on long-term efficacy and impact on quality of life.