Lichen Planus – A Refractory Autoimmune Disorder

April 2023 in “ IP Indian journal of clinical and experimental dermatology ”

Sunil Chaudhry, G. Manmohan, K Aishwarya Yadav, G. Madhulika

lichen planus oral lichen planus CD8+ cytotoxic T lymphocytes cytokines TNF-α IL-10 IFN-γ IL-4 IL-8 hyperpigmentation scarring alopecia antihistamines corticosteroids retinoids immunomodulators phototherapy immunosuppressives griseofulvin chloroquine derivatives LP OLP T lymphocytes tumor necrosis factor alpha interleukin-10 interferon gamma interleukin-4 interleukin-8 hair loss steroids vitamin A derivatives immune system modulators light therapy immune system suppressants antifungal antimalarial

Studysummary This article reviews the pathogenesis, complications, and management of lichen planus, especially its persistent oral form, and highlights the need for further prospective studies.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer ·

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This study found that patients with severe alopecia areata had significantly lower serum zinc levels compared to healthy controls, and a negative correlation between zinc levels and disease severity was observed, suggesting that zinc assessment and supplementation trials may be warranted in this population.