8 citations
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May 2020 in “Arthritis research & therapy” This study found that dutasteride affected spinal bone formation in curdlan-treated SKG mice, while DHT treatment reduced osteoblast differentiation in vitro, suggesting that DHT inhibition might unexpectedly increase spinal ankylosis progression in ankylosing spondylitis patients.
November 2018 in “Studies in Medical Sciences” This study found that Finasteride microemulsion gel significantly reduced acne lesions in men compared to a control treatment over three months.
5 citations
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November 2013 in “Case reports in dermatology” This case report details a 57-year-old woman with frontal fibrosing alopecia who developed hyperpigmentation after treatment with dutasteride and pimecrolimus, highlighting no previously reported hyperpigmentation association with this combination.
46 citations
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August 2016 in “Journal of The American Academy of Dermatology” This study found that lifestyle factors such as diet, personal history, and psychological stress may be linked to the development of adult female acne, based on observed associations in a case-control setting.
11 citations
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April 2018 in “Journal of Dermatology” In a randomized study, men treated with dutasteride for androgenetic alopecia experienced sexual adverse events at twice the rate of those on placebo during 24 weeks, but these events were mild, moderate, and resolved after treatment.
This study evaluated the therapeutic response of an Afro-descendant patient with non-scarring alopecia after prolonged use of alkaline straighteners and mechanical traction, highlighting the susceptibility of Afro hair to chemical and mechanical damage due to its structure.
1 citations
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November 2022 in “Journal of the Academy of Consultation-Liaison Psychiatry” This case study reports on a 44-year-old male exhibiting persistent neuropsychiatric symptoms described as Post-Finasteride Syndrome after discontinuing long-term finasteride use, highlighting the ongoing debate regarding its classification as a true disease process.
4 citations
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May 2018 in “BMC Musculoskeletal Disorders” This study found that dutasteride is not associated with an increased risk of osteoporosis or fractures in older men compared to finasteride, suggesting dutasteride does not adversely affect bone health.
14 citations
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June 2012 in “Stem Cells” This study found that depletion of TACE in mouse hair follicles led to impaired stem cell maintenance and hair loss, implicating TACE and EGFR signaling in hair follicle stem cell homeostasis.
5 citations
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August 2014 in “Journal of The American Academy of Dermatology” This article notes slow progression and spontaneous stabilization in untreated cases of a specific scarring alopecia and reports no new results; the authors call for randomized trials to confirm the treatment's benefit.
1 citations
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November 2022 in “Journal of Investigative Dermatology” This study found that ALRN-6924, a clinical-stage dual inhibitor, can selectively protect human scalp hair follicles from paclitaxel-induced toxicity and damage by inducing transient cell cycle arrest in healthy cells without affecting cancer cells, potentially reducing chemotherapy-induced alopecia.
July 2020 in “Environmental Science and Pollution Research” This study found that finasteride and melengestrol acetate exhibit varying levels of toxicity to freshwater mussels, amphipods, and mayflies, but current environmental concentrations suggest minimal direct effects on these aquatic invertebrates.
10 citations
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September 2021 in “The FASEB Journal” This study found that ACKR2 plays a crucial role in reducing inflammatory skin fibrosis and promoting inflammation resolution through IFN‐β production, limiting tissue scarring.
This glossary defines medical and anatomical terms but reports no new research findings.
2 citations
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June 2021 in “Sultan Qaboos University medical journal” This case report presents three sisters with familial frontal fibrosing alopecia, making it the 25th documented familial case, with treatment results observed in one sister.
16 citations
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December 2016 in “ecancermedicalscience” This study suggests that ATR-FT-IR spectral analysis of hair fibres may detect breast cancer through increased lipid content changes linked to cancer presence.
31 citations
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September 2012 in “Human Brain Mapping” In this study, patients with seasonal affective disorder were found to have increased functional connectivity in certain brain networks and higher low-frequency fluctuations compared to healthy controls, which aligns with their attentional and psychomotor symptoms.
1 citations
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December 2006 in “Annals of the New York Academy of Sciences” Green algae can break down finasteride, reducing environmental harm.
81 citations
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June 2014 in “American Journal of Men's Health” This study highlights that adverse effects from finasteride may persist in men after discontinuation, indicating a potential "post-finasteride syndrome.
July 2010 in “Hair transplant forum international” This article discusses the first international certification examination by the American Board of Hair Restoration Surgery, with no new research findings reported.
12 citations
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February 2003 in “European Urology Supplements” Dutasteride reduces DHT more effectively than finasteride.
11 citations
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August 2007 in “Bioorganic & Medicinal Chemistry Letters” This study found that among the tested analogs, compound 4e was the most effective in inhibiting wax esters in vivo in the Golden Syrian hamster ear model.
15 citations
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January 2008 in “Annales de Toxicologie Analytique” This study concluded that standard decontamination procedures do not fully remove external contamination from post mortem hair specimens, which complicates using hair analysis to assess long-term drug exposure.
6 citations
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December 2016 in “Journal of Dermatology” The source does not provide an abstract for this letter to the editor, so specific results regarding the long-term efficacy and safety of dutasteride for male androgenetic alopecia are not reported.
5 citations
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June 2019 in “Open Forum Infectious Diseases” This report describes six cases of hair loss in African American women after switching to tenofovir alafenamide, suggesting it as a possible adverse effect in this population.
5 citations
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February 2018 in “Military medicine” This case study reports a U.S. Naval fighter pilot with recurrent central serous retinopathy who became the first to receive a waiver for unrestricted flight despite permanent defective visual acuity.
January 2026 in “Cronfa (Swansea University)” Finasteride and dutasteride may increase the risk of depression and suicidality, so patients should be monitored closely.
November 2023 in “Indian Dermatology Online Journal” This study found that tofacitinib was safe and effective for patients with severe or treatment-resistant alopecia areata, alopecia totalis, and alopecia universalis, resulting in significant hair regrowth for most participants.