Hyperpigmentation Following Treatment of Frontal Fibrosing Alopecia

    November 2013 in “ Case reports in dermatology ”
    Irma Margarita Pérez-Rodríguez, Martha Elena García-Meléndez, Kristian Eichelmann, Osvaldo Vázquez‐Martínez, Jorge Ocampo‐Candiani
    TLDR A woman's skin darkened after using dutasteride and pimecrolimus for hair loss, but improved when she stopped the medications and protected her skin from light.
    A 57-year-old postmenopausal woman with frontal fibrosing alopecia (FFA) was treated with dutasteride and pimecrolimus, which initially improved her condition. However, she developed hyperpigmentation on her joints and face after 8 months. Discontinuation of the treatment and use of photoprotection led to an 80% improvement in hyperpigmentation after 5 months. This case highlighted a previously unreported side effect of hyperpigmentation associated with the combination of dutasteride and pimecrolimus, suggesting the need for further studies to evaluate this association.
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