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The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.

MicroRNAs are crucial for controlling skin development and healing by regulating genes.

UVB radiation harms hair growth and health, causing cell death and other changes in human hair follicles.

Oral retinoids are effective for severe skin conditions but require careful use due to side effects.

Wound dressing absorbs fluid, regenerates hair follicles, and heals skin burns.

Ginseng may help treat cancer and reduce treatment side effects, but more research is needed.

Endocrine therapies for cancer significantly increase the risk of hair loss.

LGBT individuals have unique skin health needs, including higher STD risks and side effects from gender-affirming treatments, requiring dermatologists to offer knowledgeable and culturally competent care.

CYLD mutations cause a variety of skin tumors with symptoms starting around age 16, and treatments are currently limited.

Hair follicles can help wounds heal faster and this knowledge could be used to treat chronic skin ulcers, with a potential use of a special stem cell hydrogel to enhance healing.

Using fat stem cells and blood cell-rich plasma together improves healing in diabetic wounds by affecting cell signaling.

Some patients with mycosis fungoides or Sézary syndrome experience hair loss, which may be similar to alopecia areata or linked to skin lesions, possibly due to abnormal T cells, and bexarotene can help treat it.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Aging in hair follicle stem cells leads to hair graying, thinning, and loss.

Skin problems like itching, dry skin, and hair loss are more common in hepatitis C patients after interferon treatment, but lichen planus is not linked to the infection.

Cellular senescence has both cancer-blocking and cancer-promoting effects, and targeting senescent cells may improve health and lifespan.

STAT5 activation is crucial for starting the hair growth phase.

Skin organoids are a promising new model for studying human skin development and testing treatments.

Polyamines are important for hair growth, but more research is needed to understand their functions and treatment potential.

Finasteride can cause one-sided breast enlargement, which disappears after stopping the drug.

Hedychium spicatum has medicinal properties but needs more research for scientific validation and use.

New treatments targeting immune pathways show promise for severe hair loss but need more research for safety and effectiveness.

Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.

Every elderly patient had at least one skin condition, often linked to other diseases, highlighting the need for integrated skin and general healthcare in the elderly.

Safflower has been used in traditional medicine for centuries and shows promise in treating heart, brain, and inflammatory conditions, but more research is needed to ensure its safety.

Autoimmune liver diseases are likely linked to certain skin conditions like vitiligo and psoriasis.

The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.

In vivo confocal scanning laser microscopy is an effective, non-invasive way to study and measure new hair growth after skin injury in mice.