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The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Early diagnosis and treatment, using finasteride, minoxidil, or hair transplantation, improves hair loss outcomes.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Effective treatments for male pattern baldness include oral finasteride and topical minoxidil, while topical minoxidil is best for female pattern baldness.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

Voriconazole can cause serious side effects, especially in long-term use.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

New hormonal contraceptives are safer, have fewer side effects, and offer health benefits for women.

Women with PCOS may take longer to get pregnant but can have a normal family size, and should manage their overall health to reduce long-term health risks.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Alpha-hydroxy acids, like glycolic acid, safely improve skin issues and work on all skin types.

Treatments for melanin disorders exist, but more effective options needed.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Lifestyle changes improve metabolism and fertility in overweight PCOS patients; anti-obesity drugs show potential but need more research.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.