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This study found that all-trans and 9-cis retinoic acids increase steroid sulfatase activity in HL60 cells through mechanisms involving RARα/RXR heterodimers and multiple signaling pathways.

This study found that Finasteride significantly reduced the proliferation of acute myeloid leukemia cell lines by inhibiting androgen receptor activity.

Mitoxantrone is effective for treating acute leukemia, especially in older patients, with a lower risk of heart damage.

This review discusses arsenic trioxide therapy in acute promyelocytic leukemia and introduces a novel method using hair analysis to monitor arsenic exposure and correlate it with treatment timing, but reports no new clinical results.

This research reports that arsenic trioxide achieved a complete remission rate of 87% in patients with relapsed acute promyelocytic leukemia, though its use involves manageable toxicities.

In this review, the researchers found no statistically significant difference in overall survival and disease-free survival between busulfan/cyclophosphamide and total bone irradiation conditioning regimens for acute myeloid leukemia patients.

This report documented a case of thrombocytopenia and leukopenia linked to the long-term use of itraconazole in a patient with acute myelogenous leukemia.

This case report describes a 22-year-old woman who developed persistent, non-scarring hair loss and premature ovarian failure following a myeloablative umbilical cord transplant for acute myeloid leukemia.

This study reported that certain minoxidil conjugates, specifically those with spermine, methylenedianiline, and diaminofluorene, were able to induce differentiation in HL-60 acute myeloid leukemia cells without toxicity at a concentration of 10 μM.

This study reported a rare case of pityriasis rubra pilaris-like skin reaction in an 18-year-old woman after starting ponatinib treatment for relapsed Philadelphia chromosome-positive acute lymphoblastic leukemia, which resolved after treatment adjustment and did not recur over 15 months.

This paper reviews the development and implementation of CAR-T cell therapy as a significant advancement in treating pediatric hematological malignancies, particularly for children with relapsed or chemotherapy-resistant acute lymphoblastic leukemia, offering renewed remission prospects where conventional methods are ineffective.

This case report describes a 12-year-old boy who developed severe shingles with skin erosion and hair loss despite early aciclovir treatment after a stem-cell transplant for relapsed acute myeloid leukemia.

The document concludes that accurately identifying leukemia types is crucial, and the risks of cancer from finasteride need careful evaluation against its benefits.

This study reports that VP-16-213 (etoposide) shows significant therapeutic activity in several cancers including small cell bronchogenic carcinoma and certain leukemias, with hematologic toxicity being the primary side effect.

This study examined monoclonal antibodies LT-1, LT-2, and LT-7, finding they can effectively detect certain antigens on T and B cells involved in various lymphoproliferative diseases, aiding in the diagnosis of both acute and chronic lymphoid neoplasias.

This case report describes a 69-year-old woman who developed drug-induced acquired ichthyosis related to ponatinib therapy, which improved upon stopping the medication.

This case report highlights that diagnosing fungal skin infections in immunocompromised patients requires culture for accurate identification, as histologic findings alone can be misleading.

This review examines the patent literature on AKR1C3 inhibitors and suggests that although numerous potent inhibitors exist, further preclinical optimization is necessary before assessing their therapeutic potential in human diseases.

Zinc deficiency is linked to respiratory infections in children.

This case report discusses cutaneous graft versus host disease presenting as fibrosing alopecia, suggesting a mechanistic model for understanding cicatricial pattern hair loss.

This study found that pediatric cancer patients at Muhimbili National Hospital commonly experienced adverse drug reactions during chemotherapy, despite drug prescribing patterns aligning with essential medicine lists.

This review discusses the implications of renaming myelodysplastic syndromes as "myelodysplastic neoplasms" and argues that the "low-risk" label may misrepresent patient experiences and hinder research.

In this study, researchers at Muhimbili National Hospital observed that pediatric cancer patients undergoing chemotherapy frequently experienced adverse drug reactions, such as nausea and vomiting, hair loss, and neutropenia, despite drug prescribing patterns aligning with the essential medicine list.

This article discusses tretinoin, noting its approved use for acne and photoaging and its broader application in treating various dermatological conditions, but reports no new clinical findings.

The review discusses the diverse roles of WNT10B in mammary gland development, immune function, and its potential implications in cancer and regenerative processes, with no new experimental results.

This case report found that the most likely cause of the patient's seizures and brain tumor was prior radiation exposure, with seizures managed effectively using intravenous lorazepam and subsequent treatment for the brain mass.

This article reviews the role of factor Xa inhibitors like Rivaroxaban and suggests they may eventually replace vitamin K antagonists, but their side effects require further clarification.

This article presents a collection of 70 multiple choice questions designed to assist haematology and core medical trainees with diagnostic and management skills, but it provides no new clinical findings.

This study found that betibeglogene autotemcel significantly improved transfusion independence in 89% of patients with transfusion-dependent beta-thalassemia, although the high cost and manufacturing challenges may limit widespread adoption.

This review discusses the role of LGR4 in tumors, highlighting its involvement in cancer progression, metastasis, and chemotherapy resistance, as well as its regulatory effects on tumor stem cell self-renewal and stem cell characteristics, based on multiple recent studies.