Androgen Receptor Inhibition Is Involved in Finasteride-Reduced AML Cell Proliferation

    May 2023 in “ Blood cancer discovery ”
    Pang-Ting Cheng, Chieh-Lin Jerry Teng, Yu-Chiao Cheng, Mei-Chih Chen, Ho Lin
    TLDR Finasteride reduces AML cell growth by inhibiting androgen receptors.
    The study investigates the role of androgen receptor (AR) in acute myeloid leukemia (AML) and the effects of Finasteride, a 5 alpha-reductase inhibitor, on AML cell proliferation. The results show that Finasteride significantly reduces the proliferation of AML cell lines KG-1 and HL-60 by inhibiting AR phosphorylation and activation, while not affecting cell cycle-related proteins like CDK1, Cyclin A, and p21. Additionally, an increase in AKT phosphorylation was observed, suggesting a collaborative role between AR and AKT in AML cell proliferation. These findings indicate that Finasteride could potentially be used to develop new treatments for AML by targeting AR.
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