research Sensitive Skin
Sensitive skin often causes discomfort, affects many people, especially women and older adults, and should be managed with careful product selection.
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research Current Evaluation of Amenorrhea
Amenorrhea, or the absence of periods, should be evaluated by age 15 or within five years of early breast development, and is most commonly caused by conditions like polycystic ovary syndrome and hypothalamic amenorrhea.
research Epidermolysis Bullosa Simplex Keratinocytes Show Disturbed Mitochondrial Positioning and Activity
Skin cells from people with Epidermolysis Bullosa Simplex have abnormally placed and less active mitochondria.
research Keloid Pathogenesis and Fibroproliferative Properties Are Dependent on Stem Cells Regulated by the Hedgehog-Gli1 Pathway
Blocking the HEDGEHOG-GLI1 pathway can reduce keloid growth and may be a potential treatment.
research Novel Association of Trichothiodystrophy With Autoimmune Thyroiditis and Autoimmune Hemolytic Anemia: A Case Report
A child with trichothiodystrophy also had autoimmune thyroiditis and anemia, which is a new finding.
research Hypertrichosis
The document explains the types of excessive hair growth and how to manage it.
research How to Diagnose a Lipodystrophy Syndrome
The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.
research Acquired Localized Hypertrichosis Following Pressure Garment and Silicone Therapy in Burn Patients
Some burn patients grew extra hair in areas treated with pressure garments or silicone.
research Pitfalls of Midface Surgery
Midface surgery complications are generally rare and manageable with skilled surgery and informed patients.
research Impact of Laboratory Workup and Supplementation on Alopecia Patients: A Single-Center Retrospective Chart Review
Vitamin supplements may not improve hair thickness or density in patients with non-scarring hair loss.
research Review of Hair Removal in Traditional Medicine and Its Clinical Application
Traditional Korean medicine combined with modern technology may improve hair removal treatments.
research Differential Expression of Keratin and Keratin Associated Proteins Are Linked with Hair Loss Condition in Spontaneously Mutated Inbred Mice
The study investigates hair loss in spontaneously mutated inbred C57BL/6 mice, which exhibit a delayed catagen phase in the hair cycle, leading to cyclic alopecia. The research identifies significant differential expression of genes related to keratinization, such as Krt16, Alox15, and Msx2, with Krt6b levels notably higher in hair loss mice across all hair cycle stages. These findings suggest that the abnormal expression of these genes contributes to the hair loss phenotype. The study provides a model for understanding hair loss mechanisms and developing potential treatments for alopecia.
research Review of Hair Removal in Traditional Medicine and Its Clinical Application
Combining traditional hair removal methods with modern technology could improve cosmetology.
research Towards a Molecular Understanding of Hair Loss and Its Treatment
Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.
research Human Hair Growth Deficiency Is Linked to a Genetic Defect in the Phospholipase Gene LIPH
A genetic mutation in the LIPH gene causes hair loss and growth defects.
research The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling
Cathepsin L is essential for normal hair growth and development.
research Activating Wnt/β-Catenin Signaling Pathway for Disease Therapy: Challenges and Opportunities
Using drugs to activate the Wnt/β-catenin pathway has potential for treating diseases but also presents challenges.
research Dlx3 Is a Crucial Regulator of Hair Follicle Differentiation and Cycling
Dlx3 is essential for hair growth and regeneration.
research Coats' Plus: A Progressive Familial Syndrome of Bilateral Coats' Disease, Characteristic Cerebral Calcification, Leukoencephalopathy, Slow Pre- and Post-Natal Linear Growth, and Defects of Bone Marrow and Integument
Coats' Plus is a genetic disorder with eye abnormalities, brain calcification, poor growth, bone and skin issues, and movement disorders.
research Role of FGFR2-Signaling in the Pathogenesis of Acne
Increased FGFR2b signaling, influenced by androgens, plays a role in causing acne.
research Stress and Aging: Effects of Disturbed Calcium Metabolism on Aging in a Progeria-Like Syndrome Induced by Dihydrotachysterol in Rats
Anabolic steroids may help prevent aging effects by reducing toxicity, not by their usual functions.
research Generalized Hair-Follicle Hamartoma
The document described a unique syndrome characterized by progressive baldness due to a distinctive hamartoma of the hair follicle. The patient exhibited symptoms including myasthenia gravis, an enlarged sella turcica, and an abnormal urinary amino acid pattern, with a suspicion of lupus erythematosus. Initially diagnosed as alopecia universalis, multiple skin biopsies later identified a basal cell hamartoma in each hair follicle. Histochemical and electron microscopic analyses revealed the tumor's epithelial cell characteristics. The study highlighted the critical role of skin biopsy in diagnosing alopecia of unknown origin and suggested that further research into abnormal ectodermal tissues could enhance understanding of hair keratin defects.
research Role of S-Palmitoylation by ZDHHC13 in Mitochondrial Function and Metabolism in Liver
ZDHHC13 is important for normal liver function and metabolism, affecting mitochondrial activity.
research Hair and Systemic Disease
Hair loss can indicate underlying systemic diseases and addressing these can sometimes reverse the hair loss.
research Roles of Tumor Suppressors in Regulating Tumor-Associated Inflammation
Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.
research Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations
Deleting MED1 in skin cells causes hair loss and skin changes.
research Hutchinson-Gilford Progeria Syndrome: Current Status and Prospects for Gene Therapy Treatment
Gene therapy has potential as a future treatment for Hutchinson-Gilford progeria syndrome.
research Finasteride-Associated Male Infertility
Finasteride may worsen infertility in men with existing issues, but stopping it can improve sperm health.
research Scalp Dysesthesia Related to Cervical Spine Disease
Most women with weird scalp feelings had neck spine problems, and some got better with gabapentin treatment.
research Alopecia Areata: A Possible Extraintestinal Manifestation of Crohn's Disease
Alopecia Areata might be linked to Crohn's disease.