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    Did you mean 7,12-Dimethylbenz[a]anthracene?
    Glossary 7,12-Dimethylbenz[a]anthracene

    potent chemical carcinogen used in cancer research

    7,12-Dimethylbenz[a]anthracene (DMBA) is a potent chemical carcinogen commonly used in research to induce cancer in laboratory animals for the study of cancer mechanisms and potential treatments. It is a polycyclic aromatic hydrocarbon that can cause mutations in DNA, leading to the development of tumors.

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    1. Ornithine decarboxylase expression in cutaneous papillomas in SENCAR mice is associated with altered expression of keratins 1 and 10. PubMed · 1994 · 33 citations
    2. The Vitamin D Receptor as Tumor Suppressor in Skin Advances in experimental medicine and biology · 2020 · 55 citations
    3. Overexpression of Hedgehog Signaling Is Associated with Epidermal Tumor Formation in Vitamin D Receptor–Null Mice Journal of Investigative Dermatology · 2011 · 100 citations
    4. Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis 2008 · 148 citations
    5. Ligand‐Independent Actions of the Vitamin D Receptor: More Questions Than Answers JBMR plus · 2021 · 11 citations
    6. Chemically induced skin tumors arise from long-lived stem cells of the upper hair follicle Science · 2026
    7. Comparison of the acute ultraviolet photoresponse in congenic albino hairless C57BL/6J mice relative to outbred SKH1 hairless mice Experimental dermatology · 2016 · 8 citations
    8. A Humanized Mouse Model of Hereditary 1,25-Dihydroxyvitamin D–Resistant Rickets Without Alopecia Endocrinology · 2014 · 25 citations
    9. Melatonin membrane receptors in peripheral tissues: Distribution and functions Molecular and Cellular Endocrinology · 2012 · 506 citations
    10. Activated Hair Follicle Stem Cells and Wnt/β-catenin Signaling Involve in Pathnogenesis of Sebaceous Neoplasms International Journal of Medical Sciences · 2014 · 19 citations
    11. Novel small molecules downregulate CDK1 expression and inhibit Wnt/β-catenin signaling in cutaneous squamous cell carcinoma by targeting its distinct tumor-specific cellular landscape Experimental & Molecular Medicine · 2025
    12. New insights into the functions of Cox-2 in skin and esophageal malignancies Experimental & Molecular Medicine · 2020 · 54 citations
    13. Extraskeletal actions of vitamin D Annals of the New York Academy of Sciences · 2016 · 119 citations
    14. 5α-Reduced glucocorticoids: a story of natural selection Journal of Endocrinology · 2011 · 46 citations
    15. Wnt Signaling in Skin Development, Homeostasis, and Disease Cold Spring Harbor Perspectives in Biology · 2012 · 260 citations
    16. Hair Follicle Cloning and Stem Cells Updates in clinical dermatology · 2024
    17. Protein Kinase C Epsilon Signals Ultraviolet Light‐induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism<sup>¶</sup> Photochemistry and Photobiology · 2005 · 3 citations
    18. The regulation of skin homeostasis, repair and the pathogenesis of skin diseases by spatiotemporal activation of epidermal mTOR signaling Frontiers in Cell and Developmental Biology · 2022 · 35 citations
    19. Immunological challenges associated with artificial skin grafts: available solutions and stem cells in future design of synthetic skin Journal of Biological Engineering · 2017 · 105 citations
    20. The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted Current Biology · 1998 · 153 citations
    21. Beyond Wavy Hairs American Journal Of Pathology · 2008 · 160 citations
    22. Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis American Journal Of Pathology · 2006 · 100 citations
    23. Vitamin D Receptor, UVR, and Skin Cancer: A Potential Protective Mechanism Journal of Investigative Dermatology · 2008 · 51 citations
    24. Myricetin: A Significant Emphasis on Its Anticancer Potential via the Modulation of Inflammation and Signal Transduction Pathways International Journal of Molecular Sciences · 2023 · 54 citations
    25. Photobiomodulation: A Systematic Review of the Oncologic Safety of Low-Level Light Therapy for Aesthetic Skin Rejuvenation Aesthetic Surgery Journal · 2023 · 25 citations
    26. 712 A small molecule modulator of the wnt pathway (SM04554) as a potential topical treatment for androgenetic alopecia (AGA) Journal of Investigative Dermatology · 2017 · 1 citations
    27. 712 Using scanning electron microscopy to elucidate the role of hair shaft malformation in the pathogenesis of Central Centrifugal Cicatricial Alopecia Journal of Investigative Dermatology · 2020
    28. Nanocarriers for Improved Delivery of Angiotensin-(1-7) Elsevier eBooks · 2015
    29. Alterations in the expression of specific epidermal keratin markers in the hairless mouse by the topical application of the tumor promoters 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin and the phorbol ester 12-<i>O</i>-tetradecanoylphorbol-13-acetate Carcinogenesis · 1987 · 12 citations
    30. LA IGLESIA MOZÁRABE EN TIERRAS DE JAÉN (712-1157) Boletín del Instituto de Estudios Giennenses · 2005