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Glossary4-Methylaminorex

synthetic stimulant drug with effects similar to methamphetamine

4-Methylaminorex, also known as 4-MA or U4Euh, is a synthetic stimulant drug that has effects similar to methamphetamine. It was originally developed in the 1960s as an appetite suppressant but is now primarily known for its recreational use due to its euphoric and stimulating properties. It is classified as a Schedule I controlled substance in many countries, indicating a high potential for abuse and no accepted medical use.

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Discovery of 7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1<i>H</i>-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

research Discovery of 7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1<i>H</i>-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

6 citations , January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin”

A new compound shows promise as a topical treatment for hair loss.

research Low-level light-assisted photodynamic therapy using a wearable cap-like device for the treatment of actinic keratosis of the scalp

6 citations , March 2019 in “Photodiagnosis and Photodynamic Therapy”

A wearable cap-like device using light therapy reduced scalp skin lesions by 71% and was painless.

research Acne Protection: Measures & Miseries

January 2019 in “ARC journal of pharmaceutical sciences”

Acne can be managed with various treatments and requires psychological support due to its emotional impact.

Incipient Diabetes Mellitus and Nascent Thyroid Disease Presenting as Beard Alopecia Areata: Case Report and Treatment Review of Alopecia Areata of the Beard

research Incipient Diabetes Mellitus and Nascent Thyroid Disease Presenting as Beard Alopecia Areata: Case Report and Treatment Review of Alopecia Areata of the Beard

5 citations , July 2020 in “Curēus”

Beard hair loss can signal early diabetes and thyroid issues, treatable with specific cream.

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

research Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

2 citations , May 2020 in “Journal of visualized experiments”

Controlled light treatment in mouse skin speeds up healing and hair growth.

research 491 Efficacy of oral tofacitinib in the treatment of lichen planopilaris

1 citations , May 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Oral tofacitinib significantly improves lichen planopilaris symptoms without adverse effects.

research 490 Samcyprone (diphenylcyclopropenone ointment) for the treatment of common warts

May 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Samcyprone ointment is effective for treating common warts if a sensitization reaction occurs first.

research Liposomes in dermatology today

140 citations , April 2009 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Liposomes improve drug delivery and reduce skin irritation in dermatology.

research Photodynamic and photobiological effects of light-emitting diode (LED) therapy in dermatological disease: an update

62 citations , July 2018 in “Lasers in Medical Science”

LED therapy is safe and shows potential for treating skin conditions and promoting hair growth, but more research is needed.

research Derma rollers in therapy: the transition from cosmetics to transdermal drug delivery

19 citations , October 2020 in “Biomedical Microdevices”

Derma rollers show promise for skin improvement and drug delivery, but more research is needed on their safety and effectiveness.

research The effects of narrowbands of visible light upon some skin disorders: a review

17 citations , February 2016 in “International Journal of Cosmetic Science”

Visible light can improve skin disorders and hair loss, but more research is needed to understand long-term effects.

research Alopecia Areata of the Beard: A Review of the Literature

16 citations , May 2017 in “American Journal of Clinical Dermatology”

The document concludes that more research is needed to understand and treat Beard Alopecia Areata due to limited current knowledge and evidence.

research Dermatological drugs, topical agents, and cosmetics

January 2011 in “Side effects of drugs annual”

Tretinoin gel is safe for sun exposure, but tacalcitol doesn't significantly improve non-segmental vitiligo.

research A Comprehensive Review of Acne Vulgaris

18 citations , June 2019 in “Clinical research in dermatology”

Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.

research The Antiandrogenic Action of 4–Androsten–3–one–17β– Carboxylic Acid and Its Methyl Ester on Hamster Flank Organ1

87 citations , April 1973 in “Endocrinology”

The chemicals 17βC and its methyl ester can block the effects of testosterone on hamster skin but not the effects of DHT.

research Involvement of 4‐hydroxy‐2‐nonenal in pollution‐induced skin damage

50 citations , May 2019 in “BioFactors”

Pollution increases a compound in the skin that can lead to faster aging and more inflammation.

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs

research [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs

26 citations , September 2007 in “Biochemical Pharmacology”

ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.

research New approach to 3-oxo-4-aza-5α-androst-1-ene-17β-(--butylcarboxamide)

14 citations , September 2005 in “Steroids”

A new method was developed to make finasteride for treating hair loss.

research 4 Vitamin D resistance

13 citations , April 1994 in “Baillière's clinical endocrinology and metabolism”

Some people have genetic mutations that make them resistant to vitamin D, leading to rickets even with enough vitamin D intake.

4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production

research 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production

11 citations , March 2009 in “Bioorganic & Medicinal Chemistry Letters”

Chemicals called 4-(alkylthio)- and 4-(arylthio)-benzonitrile derivatives can potentially reduce oil production on skin, which could help treat conditions like acne and hair loss.

Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production

research Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production

11 citations , October 2007 in “Bioorganic & Medicinal Chemistry Letters”

Scientists made a chemical (compound 4e) that can be applied on skin to reduce oil production, which can help with acne, but it might cause skin sensitivity to light.

Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2

research Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2

8 citations , March 2002 in “Archiv Der Pharmazie”

The compound 4c effectively inhibits the enzyme linked to hair loss.

research 4 Anti-androgens in gynaecological practice

7 citations , September 1988 in “Baillière's clinical obstetrics and gynaecology”

Cyproterone acetate is effective for treating hirsutism and acne in women by blocking androgens in the skin and also works as a contraceptive.

4-<i>O</i>-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

5 citations , July 2017 in “Biomolecules & Therapeutics”

4-O-Methylhonokiol helps protect skin cells from growth-stopping effects of a protein by regulating growth-related pathways.

research The hair growth promoting effect of 4-O-methylhonokiol

3 citations , November 2011 in “European Journal of Dermatology”

4-O-methylhonokiol from Magnolia officinalis significantly promotes hair growth.

research Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata

2 citations , December 2022 in “PNAS nexus”

SCD-153 shows promise as an effective topical treatment for alopecia areata.

research Prooxidant and antioxidant action of 4-(4-phenoxybenzoyl)benzoic acid derivatives

2 citations , January 2004 in “Biopolymers”

4-(4-Phenoxybenzoyl)benzoic acid derivatives can both increase and decrease certain types of reactive oxygen species, and may be relevant to hair loss.

4‐octyl itaconate alleviates cisplatin‐induced ferroptosis possibly via activating the <scp>NRF2</scp>/<scp>HO</scp>‐1 signalling pathway

research 4‐octyl itaconate alleviates cisplatin‐induced ferroptosis possibly via activating the NRF2/HO‐1 signalling pathway

1 citations , March 2024 in “Journal of Cellular and Molecular Medicine”

4-octyl itaconate may prevent hearing loss caused by the drug cisplatin by activating certain cell protection pathways.

research Integrating multi-omics analyses of Nonomuraea dietziae to reveal the role of soybean oil in [(4′-OH)MeLeu]4-CsA overproduction

1 citations , July 2017 in “Microbial Cell Factories”

Adding soybean oil to Nonomuraea dietziae increases production of a beneficial compound by improving metabolism and enzyme systems.

research Flavonoid 4,4′-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy

February 2024 in “Redox biology”

The substance DMC helps get rid of aging cells by triggering a process that causes cell death, which could treat age-related diseases.