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    Glossary 4-azasteroid

    synthetic compound mimicking steroids with a nitrogen atom

    A 4-azasteroid is a type of synthetic compound that mimics the structure of steroids but includes a nitrogen atom at the fourth position in its chemical structure. These compounds are often used in medical treatments to inhibit enzymes like 5-alpha-reductase, which can help manage conditions such as benign prostatic hyperplasia and androgenic alopecia (hair loss).

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    1. Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-diene or 4,6-diene 20-ones and 4-Azasteroid 20-Oximes Molecules · 2011 · 186 citations
    2. 13C-NMR study of 4-azasteroids in solution and solid state Steroids · 2002 · 25 citations
    3. Synthesis of a 4-azasteroid hormones compound Xiandai huagong · 2009
    4. Azasteroids as inhibitors of testosterone 5α-reductase in mammalian skin 1993 · 34 citations
    5. Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase Bioorganic & Medicinal Chemistry · 1997 · 5 citations
    6. An overview on 5α-reductase inhibitors Steroids · 2009 · 219 citations
    7. Steroid 5α-Reductase Inhibitors Mini-reviews in Medicinal Chemistry · 2003 · 42 citations
    8. 12 Treatment of hirsutism with 5α-reductase inhibitors Clinics in endocrinology and metabolism · 1986 · 28 citations
    9. 5α‐Reductase inhibitors and prostatic disease Clinical endocrinology · 1994 · 21 citations
    10. Novel inhibitors of 5α-reductase Expert Opinion on Therapeutic Patents · 2002 · 20 citations
    11. 5α-Reductase Inhibitors, Chemical and Clinical Models Steroids · 1998 · 17 citations
    12. A Connection between the Mitochondrial Permeability Transition Pore, Autophagy, and Cerebral Amyloidogenesis Journal of proteome research · 2008 · 14 citations
    13. Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases Current Medicinal Chemistry · 2016 · 11 citations
    14. A concise review- Development of an analytical method and validation of dutasteride Current Trends in Pharmacy and Pharmaceutical Chemistry · 2025
    15. Dutasteride in Androgenetic Alopecia: An Update Current Clinical Pharmacology · 2017 · 27 citations
    16. Alopecia - the search for novel agents continues Expert Opinion on Therapeutic Patents · 1997 · 11 citations
    17. Pharmacodynamic modeling of finasteride, a 5 alpha-reductase inhibitor. PubMed · 1995 · 7 citations
    18. Species Differences in Prostatic Steroid 5<i>α</i>-Reductases of Rat, Dog, and Human Endocrinology · 1985 · 193 citations
    19. FORMULATION AND EVALUATION OF FINASTERIDE SUSTAINED-RELEASE MATRIX TABLETS USING DIFFERENT RATE CONTROLLING POLYMERS Universal journal of pharmaceutical research · 2016 · 3 citations
    20. FINASTERIDE AS A TREATMENT FOR MALE ANDROGENETIC ALOPECIA e-Jurnal Medika Udayana · 2013
    21. Synthesis of N-Substituted 3-Oxo-17b- carboxamide-4-aza-5a-androstanes and the Tautomerism of 3-Oxo-4-aza-5-androstenes Heterocycles · 1998 · 4 citations
    22. Crystal Structure of 3-Oxo-4-Aza-5-Alpha-Androstone-17 β-Tert-Butyl Carboxamide with an O···H–(C, N) Acceptor Four-Center Hydrogen Bond Journal of Chemical Crystallography · 2008 · 2 citations
    23. Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens Journal of Medicinal Chemistry · 1995 · 12 citations
    24. New approach to 3-oxo-4-aza-5α-androst-1-ene-17β-(--butylcarboxamide) Steroids · 2005 · 14 citations
    25. Evaluation of New Pregnane Derivatives as 5.ALPHA.-Reductase Inhibitor. Chemical & Pharmaceutical Bulletin · 2001 · 23 citations
    26. New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors. Chemical & Pharmaceutical Bulletin · 2001 · 22 citations
    27. Recent advances in thiasteroids chemistry Steroids · 2006 · 37 citations
    28. Generation of comparative pharmacophoric model for steroidal 5α-reductase I and II inhibitors: A 3D-QSAR study on 6-azasteroids Steroids · 2015 · 13 citations
    29. Experimental Assessment of 3-<i>meta</i>-Pyridine-1,2,4-Oxadiazole Deoxycholic Acid Derivative as a Prototype of 5-α-Reductase Inhibitors <i>in silico</i> and <i>in vivo</i> Models Bioorganičeskaâ himiâ · 2023
    30. Selective induction of apoptosis in the hamster flank sebaceous gland organ by a topical liposome 5-α-reductase inhibitor: A treatment strategy for acne Journal of Dermatology · 2010 · 8 citations