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Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

The enzyme 17β-HSD type 2 mainly performs oxidation in human sebaceous glands, which may help protect against acne.

The document says that understanding the causes of PCOS is important for treatment, especially in distinguishing the syndrome from just having cystic ovaries, and that losing weight is key for obese women with PCOS.

Insulin resistance is linked to high male hormone levels in women, often seen in those with PCOS.

Male rats have androgen receptors in their liver, which are different from proteins that bind estrogen.

Parathyroid hormones are important for hair growth, but their use in treating hair loss from chemotherapy is still uncertain.

Minoxidil boosts elastin production, potentially helping skin diseases.

The conclusion is that young women with excessive hair growth should be quickly tested for hormonal issues and treated to improve their social well-being.

Young women with nonclassic congenital adrenal hyperplasia may experience worse sexual function and mild depression compared to healthy women.

Children with classic congenital adrenal hyperplasia have thicker heart fat and are at higher risk for heart problems and early atherosclerosis.

PSA levels are higher in women with PCOS, but FAI is a more accurate marker for diagnosis.

Women with moderate body hair have higher levels of certain hormones and may benefit from treatment that increases sex hormone-binding protein.

Neuroactive steroids may affect the risk and treatment of alcohol use disorders.

Children with classic congenital adrenal hyperplasia have thicker heart fat and more heart and blood vessel risk factors, especially if their condition is not well-controlled.

Genetic mutations can affect female sexual development, requiring personalized medical care.

Early signs of PCOS in girls, like irregular periods and polycystic ovaries, suggest a need for early diagnosis and intervention to prevent further health issues.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Polycystic ovary syndrome costs the U.S. over $4 billion a year, mainly from treating related health issues.

Testosterone is important for men's sexual function, may help some women's sexual desire, while other hormones and neurotransmitters also play complex roles in sexual behavior.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.