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Did you mean ECM-receptor interaction?

Glossary ECM-receptor interaction

cells communicate with their surrounding environment through specific surface receptors

ECM-receptor interaction refers to the way cells in the body communicate with their surrounding environment, known as the extracellular matrix (ECM). This interaction is crucial for various cellular functions, including growth, movement, and survival. The ECM provides structural support to tissues, and cells have specific receptors on their surfaces that bind to ECM components, facilitating these essential processes. For professionals, this interaction is key in understanding tissue repair, cancer metastasis, and other biological phenomena.

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Research

5 / 1000+ results

research Molecular interactions of progesterone derivatives with 5α-reductase types 1 and 2 and androgen receptors

19 citations , March 2010 in “Steroids”

This study found that specific steroids, particularly 5 and 7b, decreased growth of prostate and seminal vesicles and bound to the androgen receptor, showing comparable pharmacological activity to finasteride.

Interaction Between Estrogens and Androgen Receptor Genes Microsatellites, Prostate-Specific Antigen, and Androgen Receptor Expressions in Breast Cancer

research Interaction between estrogens and androgen receptor genes microsatellites, prostate-specific antigen and androgen receptor expressions in breast cancer

6 citations , January 2010 in “Neoplasma”

In this study, researchers found that shorter CA repeats in the ERbeta gene are correlated with PSA expression, and PSA immunoexpression is associated with increased disease-free survival in breast cancer.

research Allosteric interactions prime androgen receptor dimerization and activation

1 citations , February 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study uses cryo-electron microscopy to reveal how androgen receptor forms a non-obligate dimer to bind DNA, with implications for prostate cancer development.

research Intermolecular NH 2 -/Carboxyl-terminal Interactions in Androgen Receptor Dimerization Revealed by Mutations That Cause Androgen Insensitivity

2 citations , July 2021 in “UNC Libraries”

This study suggests that residues Val-889 and Arg-752 in the androgen receptor's steroid binding domain are crucial for NH2-/carboxyl-terminal interaction, affecting receptor stability and function.

research Interaction of spironolactone with rat skin androgen receptor

23 citations , July 1979 in “Canadian journal of biochemistry”

This study found that administering spironolactone or canrenone to castrated male rats significantly decreased the availability of cytoplasmic androgen receptor binding sites, suggesting canrenone mediates spironolactone's antiandrogenic effects in skin.

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Community Join

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community Galenic lotion. Science behind the components

in Treatment 1 upvotes 1 year ago

A user is considering a hair loss treatment lotion containing minoxidil, adenosine, caffeine, melatonin, and azelaic acid, questioning the interaction between caffeine and adenosine receptors. Another user suggests adding a topical anti-DHT ingredient like spironolactone, noting it should not be taken orally by men.

community Breezula phase 3 results said to be released next month

26 upvotes 1 year ago

Breezula's phase 3 results are expected soon, with discussions on the effectiveness of androgen receptor antagonists like spironolactone and the potential of GT20029. Users express skepticism about new treatments and discuss the complexities of male pattern baldness, often relying on finasteride despite its side effects.

community Alternatives/unorthodox hairloss protocols to the big three

in Chat 1 upvotes 8 months ago

The conversation discusses alternative and unorthodox hair loss treatments, including RU58841, nandrolone, and dianabol, as well as theoretical approaches involving high doses of estrogen and selective estrogen receptor modulators. These methods are considered extreme and potentially harmful but are explored for those unable to tolerate traditional 5-alpha reductase inhibitors.

community End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁

276 upvotes 6 months ago

GT20029 is a new hair loss treatment in Phase 3 trials in China, using PROTAC technology to target androgen receptors, potentially with fewer side effects than finasteride and minoxidil. VDPHL01, a second-generation minoxidil, is also mentioned as potentially more effective.

community Most Promising Future Hair Loss Treatments In 2026

83 upvotes 1 week ago

Promising hair loss treatments in 2026 include GT20029, a topical androgen receptor degrader, and VDPHL01, an extended-release oral minoxidil, both offering safer alternatives with fewer side effects. Other treatments like sublingual minoxidil, OND-1, JW0061, TDM-105795, and AMP-303 are also being explored.

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Learn

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learn Pyrilutamide

highly targeted anti-androgen that might have minimal systemic effects

learn Bicalutamide

a nonsteroidal anti-androgen, most commonly used orally for women

learn Stem Cell Factor

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Epidermal Growth Factor

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