Emerging Roles of Steroid-Binding Globulins

April 2006 in “ Hormone and metabolic research ”

Jack D. Caldwell, Funmilayo G. Suleman, Shih-Yun Chou, Robert A. Shapiro, Z. Herbert, Gustav F. Jirikowski

sex hormone-binding globulin corticosteroid-binding globulin steroid hormone hormone availability receptor interactions cellular uptake hormone-related disorders SHBG CBG

TLDR Steroid-binding globulins have important roles beyond just transporting steroids.

The document reviewed the emerging roles of steroid-binding globulins, focusing on their functions beyond traditional steroid transport. It highlighted that these globulins, such as sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG), played significant roles in modulating steroid hormone action at the cellular level. The review discussed how these proteins influenced hormone availability, receptor interactions, and cellular uptake, impacting various physiological processes. The authors emphasized the importance of understanding these mechanisms for developing new therapeutic strategies for hormone-related disorders.

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