TLDR Steroid-binding globulins have important roles beyond just transporting steroids.
The document reviewed the emerging roles of steroid-binding globulins, focusing on their functions beyond traditional steroid transport. It highlighted that these globulins, such as sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG), played significant roles in modulating steroid hormone action at the cellular level. The review discussed how these proteins influenced hormone availability, receptor interactions, and cellular uptake, impacting various physiological processes. The authors emphasized the importance of understanding these mechanisms for developing new therapeutic strategies for hormone-related disorders.
16 citations
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February 2018 in “European Journal of Endocrinology” Diagnosing hyperandrogenism in women is complex and requires accurate testing methods and consideration of SHBG levels.
131 citations
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September 2017 in “Molecular and Cellular Endocrinology” The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.
60 citations
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January 2023 in “Biogerontology” Adequate testosterone is crucial for men's health and quality of life, but its decline with age needs more research.
658 citations
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June 2003 in “Endocrine reviews” Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.
51 citations
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April 1999 in “The Journal of Steroid Biochemistry and Molecular Biology” Testosterone replacement may improve sexual desire and bone health in women with low androgen levels, but more research is needed on its long-term safety.
24 citations
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September 2001 in “Journal of The American Academy of Dermatology” Women's ovarian hormones and adrenal androgens change throughout life, affecting hair loss and health.
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