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research Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

119 citations , November 2016 in “American journal of human genetics”

This study reports the discovery of mutations in the PADI3, TGM3, and TCHH genes as molecular genetic causes of uncombable hair syndrome in children, indicating an autosomal-recessive inheritance pattern.

research A Nonredundant Human Protein Chip for Antibody Screening and Serum Profiling

117 citations , September 2003 in “Molecular & cellular proteomics”

This study demonstrated the development of high-density protein microarrays allowing for antibody binding characterization and serum profiling from patients with autoimmune diseases, suggesting potential for diagnostic marker discovery.

research Clinical Use of a Protein-Sparing Modified Fast

104 citations , November 1978 in “JAMA”

This article reviews the challenges of fasting and dietary regimens in producing sustained weight loss and reports no new research findings or results.

research Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation

60 citations , January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that inhibiting PKC-β activity with bisindolylmaleimide reduces pigmentation in the skin and hair of guinea pigs and mice by preventing tyrosinase activation.

research Androgen Receptors and Androgen-Dependent Initiation of Protein Synthesis in the Prostate

59 citations , January 1976 in “Vitamins and hormones”

This chapter discusses androgen receptors and protein synthesis in the prostate, reporting that DHT-dependent receptor protein translocation increases protein-synthesizing activity after androgen injection in rat models.

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Community Join

5 / 634 results

community Protein's role in hair growth is more nuanced than just quantity

in Technology 5 upvotes 5 months ago

Protein's role in hair growth is complex, with specific amino acids like cysteine being crucial for effective hair growth. Users discussed using l-cysteine supplements, noting reduced hair loss and faster growth, though some experienced digestive issues.

community What's the full story on whey protein (isolate), BCAA's and accelerated balding?

5 upvotes 5 years ago

Whey protein and BCAAs may increase testosterone levels, potentially accelerating hair loss, but opinions vary on their impact. Some users suggest monitoring diet and hair health, while others believe the effect is minimal compared to DHT's role in balding.

community Shampoo + Protein shake causing hair shedding?

in Ketoconazole 1 year ago

The user started using ketoconazole shampoo and whey protein shakes and noticed increased hair shedding, seeking advice on whether these could be the cause. Another user shared their experience with hair loss after starting protein shakes and mentioned using finasteride, which eventually improved their hair condition.

community Korean scientists breakthrough in hair regeneration targeting CXXC5 protein and WNT Signaling Pathway

53 upvotes 8 years ago

A potential non-invasive topical treatment targeting the WNT Signaling Pathway for hair regeneration is being researched, with positive results on human hair follicle cells. Current effective treatments for hair loss include Minoxidil, finasteride, and hair transplantation.

community Derm told me that my whey protein usage is speeding up hair loss?

26 upvotes 5 months ago

Whey protein is unlikely to cause hair loss, and some users suggest it might be beneficial if dietary protein is insufficient. Hair loss is generally considered genetic, and there is skepticism about the dermatologist's advice to switch from whey protein to whole foods.

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Learn

8 / 27 results

learn SCUBE3

What is SCUBE3 and why is it being studied as a potential breakthrough for hair regrowth? SCUBE3 is a signaling protein being studied for its potential to promote hair regrowth.
How does SCUBE3 work on hair follicles compared to treatments like minoxidil or finasteride? Laboratory research in mice reports that SCUBE3, a protein released by dermal papilla cells, signals dormant follicles to grow through the TGF-β pathway downstream of Hedgehog; minoxidil and finasteride instead work on blood flow to the follicle and on DHT, and unlike SCUBE3 they have decades of human trial data behind them. SCUBE3 has not been tested in human clinical trials and is not available as a medicine.
Is SCUBE3 available in topical or injectable form, and how is it usually applied in studies? SCUBE3 is not available as a topical or injectable treatment and is not an approved medicine. In the published research it was delivered by microinjecting the recombinant protein into mouse skin and into cultured or grafted human follicles; there are no human clinical trials.

learn L-cysteine

What is L-cysteine, and why is it often included in hair growth supplements? L-cysteine supports hair growth by strengthening keratin, the main protein in hair.

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stem Cell Factor

learn Follistatin

What is follistatin, and how does it influence hair follicle growth and regeneration? Follistatin blocks activin and related growth-inhibiting proteins, which in laboratory and animal work is described as keeping hair follicles in their growth phase; the only verifiable human evidence is a single small 2011 phase 1 injection trial, so follistatin remains experimental and is not an approved hair-loss treatment.

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