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Did you mean Protein Kinase C?

Glossary Protein Kinase C

enzymes that regulate various cellular functions by phosphorylating proteins

Protein Kinase C (PKC) is a family of enzymes that play a crucial role in several cellular processes, including cell growth, differentiation, and apoptosis (programmed cell death). These enzymes are activated by signals such as increases in the concentration of calcium ions or diacylglycerol (DAG), and they function by phosphorylating various target proteins, thereby altering their activity. PKC is significant in many physiological and pathological processes, making it a key focus in research related to cancer, cardiovascular diseases, and neurological disorders.

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research Ornithine Decarboxylase Expression Leads to Translocation and Activation of Protein Kinase CK2 in Vivo

52 citations , May 1997 in “Journal of Biological Chemistry”

This study suggests that polyamines regulate CK2 enzyme activity and its subcellular distribution, as demonstrated in mouse models and cell cultures with elevated levels of ornithine decarboxylase.

research Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin

5 citations , February 2019 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that in a mouse model of Leigh syndrome, rapamycin alters brain proteome and may extend survival by targeting protein kinase C.

research PKC downregulation upon rapamycin treatment attenuates mitochondrial disease

26 citations , December 2020 in “Nature metabolism”

Martin-Perez et al. show that rapamycin's beneficial effects in a mouse model of Leigh syndrome are linked to the downregulation of protein kinase C.

research Constitutive Internalization of the Leucine-rich G Protein-coupled Receptor-5 (LGR5) to the Trans-Golgi Network

58 citations , February 2013 in “Journal of Biological Chemistry”

This study identifies specific molecular components involved in the intracellular trafficking of LGR5, revealing mechanisms that differ from typical GPCR recycling processes.

research ENZYMES

1 citations , November 2011 in “British journal of pharmacology”

This abstract provides a comprehensive overview of enzyme classification, function, and interaction with drugs, but does not present new research findings.

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community Korean scientists breakthrough in hair regeneration targeting CXXC5 protein and WNT Signaling Pathway

53 upvotes 8 years ago

A potential non-invasive topical treatment targeting the WNT Signaling Pathway for hair regeneration is being researched, with positive results on human hair follicle cells. Current effective treatments for hair loss include Minoxidil, finasteride, and hair transplantation.

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