Search
for

    Did you mean Protein Kinase C inhibitors?
    Glossary Protein Kinase C inhibitors

    blockers that prevent enzyme activity affecting cell growth and differentiation

    Protein Kinase C (PKC) inhibitors are substances that block the activity of Protein Kinase C, an enzyme involved in various cellular processes such as cell growth, differentiation, and apoptosis. By inhibiting PKC, these blockers can potentially be used to treat conditions like cancer, cardiovascular diseases, and certain skin disorders, including alopecia, where abnormal PKC activity is implicated.

    Related Terms

    Research 10 of 1000+

    1. Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation 2004 · 60 citations
    2. Bisindolylmaleimide Protein-Kinase-C Inhibitors Delay the Decline in DNA Synthesis in Mouse Hair Follicle Organ Cultures Skin Pharmacology and Physiology · 1997 · 11 citations
    3. Several Selective Protein Kinase C Inhibitors Including Procyanidins Promote Hair Growth Skin pharmacology and physiology · 2000 · 32 citations
    4. Protein Kinase C Downregulation upon Rapamycin Treatment Attenuates Neuroinflammation and Mitochondrial Disease Innovation in aging · 2020
    5. Foxn1 promotes keratinocyte differentiation by regulating the activity of protein kinase C Differentiation · 2007 · 26 citations
    6. Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 5 citations
    7. Interleukin-1β Is Differentially Expressed by Human Dermal Papilla Cells in Response to PKC Activation and Is a Potent Inhibitor of Human Hair Follicle Growth in Organ Culture Journal of interferon & cytokine research · 1997 · 38 citations
    8. Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. PubMed · 2003 · 26 citations
    9. Abstract 2559: Targeting mTORC1 may provide selectivity for inhibiting proliferation of hair follicle stem/progenitor cells during tumor promotion Cancer research · 2012
    10. Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt International Journal of Oncology · 2012 · 83 citations
    All research results →

    Learn 1 of 21

    1. Procyanidin Plant polyphenol found in apples and grape seeds
    All learn results →

    Community

    — no results

    Try a deeper search in community →