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community Good News, PP405 is out on Shopee

270 upvotes 7 months ago

A product called "PP405 Hair Follicle Serum" is being sold on Shopee, claiming to cure baldness without clinical trials or FDA approval, but users are skeptical and refer to it as "snake oil." Some users discuss testing the product's contents, while others share their experiences with hair loss treatments like finasteride.

community Can pp405 revive dead follicles for long time bald people? Are those even dead? After 10+ years bald

47 upvotes 1 year ago

PP405 may revive dormant hair follicles but is unlikely to help with long-term baldness where follicles are replaced by scar tissue. It is seen as a potential adjunct to treatments like minoxidil and finasteride, but its effectiveness on deeply fibrotic or scarred areas is doubtful.

community A Short Recap on PP405 and AAD 2026

in Update 5 months ago

PP405 is a promising experimental topical treatment for alopecia that reactivates dormant hair follicles by targeting cellular energy, with large-scale trials planned for 2026. While it shows potential, it cannot regenerate permanently destroyed follicles, making hair transplants the only guaranteed solution for advanced baldness currently.

community The mechanism of androgenic alopecia

36 upvotes 11 months ago

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

community Saw an opinion on PP405 and sharing

5 months ago

PP405 is discussed as a potential adjunct therapy for hair loss, with skepticism about its effectiveness and trial results. Users mention combining it with finasteride and minoxidil for better results, while others debate the root causes of hair loss and the limitations of current treatments.

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Research

5 / 25 results

research Oestrogen functions in skin and skin appendages

68 citations , June 2005 in “Expert Opinion on Therapeutic Targets”

This review discusses the influence of oestrogens on various skin components and highlights their modulatory roles and receptor pathways, but it reports no new clinical results.

research Moxibustion improves ovarian function based on the regulation of the androgen balance

2 citations , August 2021 in “Experimental and Therapeutic Medicine”

This study suggested that moxibustion treatment before or at the early stage of diminished ovarian reserve in rats may improve ovarian function by modulating androgen balance, though its effects differ across intervention timings.

research Use of Vitamins and Minerals in the Treatment of Hair Loss: A Cross-Sectional Survey among Dermatologists in Saudi Arabia

9 citations , November 2014 in “Journal of Cutaneous Medicine and Surgery”

This study found that a majority of dermatologists in Saudi Arabia believe in using vitamins and minerals to treat hair loss but emphasized the need for more research to confirm their effectiveness.

Study of Skin Expression of MicroRNA-146a in Patients with Alopecia Areata

research Study of Skin Expression of MicroRNA-146a in Patients with Alopacia Areata

July 2018 in “Benha Journal of Applied Sciences”

In this study, researchers found that patients with alopecia areata had significantly higher levels of miR-203 in their skin compared to healthy controls.

research Beyond Minoxidil: Off-Label Therapies for Male Androgenetic Alopecia—A Systematic Review with Network Meta-Analyses

July 2026 in “Medicina”

In this network meta-analysis, the researchers reported that topical minoxidil 5% was the most effective off-label therapy for increasing hair density in men with androgenetic alopecia, while other treatments like melatonin and cetirizine showed potential benefits, highlighting a need for further comparative trials.

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Learn

7 / 801 results

learn PP405

mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

Did you know PP405 peptides can help protect your follicles from DHT? PP405 is not a peptide and does not block DHT: it is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier, aimed at waking dormant follicles. Its registered Phase 2 trial (NCT06393452) measured safety and tolerability in 78 adults with pattern hair loss; it is not approved and not for sale.

learn Verteporfin

chemical that might completely regrow follicles from hair transplant extractions

learn Dexpanthenol

precursor of vitamin B5 with hair stimulating effects

learn Latanoprost

glaucoma medication with hair follicle stimulant effects

learn Trichogen® (foligain)

learn Baicapil

Could a daily serum with Baicapil help revive dormant hair follicles before it’s too late? Yes, a daily serum with Baicapil may help revive dormant hair follicles.

learn Folic acid

How does folic acid support hair follicle health and growth at a cellular level? Folate is required for the DNA synthesis that fast-dividing hair matrix cells depend on, and severe deficiency causes anemia—but no published trial has given folic acid to people with hair loss and measured the result, so a growth effect is a mechanism, not a finding.

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Clinics

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Experts

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas