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Glossary Pilosebaceous Unit

complex skin structure including hair follicle and sebaceous gland

The pilosebaceous unit is a complex structure in the skin that includes a hair follicle, a sebaceous (oil) gland, and an arrector pili muscle. This unit is responsible for producing and growing hair, as well as secreting sebum, an oily substance that helps lubricate and protect the skin. Understanding the pilosebaceous unit is crucial for studying conditions like acne and alopecia, which involve disruptions in this system.

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research Study regarding the microscopic aspects of pilo-sebaceous units after antiandrogen treatment in hirsute women.

January 2015 in “PubMed”

In this study, the researchers observed that antiandrogen treatment with Cyproterone acetate led to atrophy of pilo-sebaceous units and may activate Langerhans cells, contributing to local inflammation.

research Culture of the human pilosebaceous unit, hair follicle and sebaceous gland

30 citations , April 2018 in “Experimental Dermatology”

This review discusses the historical development and current challenges in in vitro hair follicle culture, highlighting a need for advanced models using cell lines and tissue engineering, and reports no new results.

research Human Pilosebaceous Culture

2 citations , November 2003 in “Humana Press eBooks”

This article explains the significance of culturing the pilosebaceous unit for studying related diseases and skin epithelial stem cells, but it reports no new findings.

research Alterations in epidermal stem cells within the pilosebaceous unit in atrophic acne scars

February 2024 in “Australasian journal of dermatology”

This study found that in atrophic acne scars, inflammation infiltrates the pilosebaceous unit over time, affecting resident stem cells and hindering the normal regeneration of the epidermis and adnexal structures, leading to scarring.

Pilosebaceous Unit: Structure, Function, and Disorders

research Pilosebaceous Unit (PSU)

January 2003 in “Elsevier eBooks”

Androgens and other hormones affect hair growth and skin conditions like acne.

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community Supposedly dairy contains precursors to DHT that are already 5a-reduced and convert to DHT independent of 5a-reductase inhibition

26 upvotes 5 months ago

Dairy may contain DHT precursors that could affect hair loss and prostate health, with some users noting reduced hair shedding after eliminating dairy. Individual responses to dairy and DHT blockers vary, with some attributing hair health to diet changes and others seeing no impact.

community Why liposomal finasteride and minoxidil may be better than traditional topical solutions.

in Research/Science 2 upvotes 1 year ago

Liposomal formulations of finasteride and minoxidil may enhance drug delivery to the skin and hair follicles more effectively than traditional solutions, potentially improving treatment outcomes. However, more human clinical trials are needed to confirm these benefits.

community Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)

5 upvotes 7 months ago

Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.

community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

59 upvotes 5 months ago

Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

community Phase II topical dut study - outperforms oral fin with a minor DHT reduction

in Research/Science 61 upvotes 7 months ago

Topical dutasteride 0.05% is more effective for hair growth than oral finasteride 1mg, with minimal DHT reduction. The formulation uses castor oil and MCTs for better absorption but is not widely available until 2028.

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