Search

for
Search:

Did you mean Phosphodiesterase Inhibitors?

GlossaryPhosphodiesterase Inhibitors

block enzymes that break down cyclic nucleotides

Phosphodiesterase Inhibitors (PDE Inhibitors or PDEIs) are a class of drugs that block the action of phosphodiesterase enzymes, which are responsible for breaking down cyclic nucleotides like cAMP and cGMP. By inhibiting these enzymes, PDE inhibitors can increase the levels of these cyclic nucleotides, leading to various therapeutic effects such as vasodilation, anti-inflammatory actions, and improved cardiac function. These drugs are used to treat conditions like erectile dysfunction, pulmonary hypertension, and certain types of heart failure.

Related Terms

Learn

1 / 1 results

learn Caffeine

the stimulant you know and love can be used topically to stimulate hair

Research

5 / 411 results

research Relationship Between Serum Concentrations, Hemodynamic Effects, and Cardiovascular Lesions in Dogs Treated with Minoxidil

29 citations, October 1996 in “Toxicology and Applied Pharmacology”

Higher minoxidil doses in dogs cause faster heart rate, lower blood pressure, and heart issues.

research Evaluation of Biological Activity Exerted by an Aza-Bicyclocarboxylic Acid Derivative Using an Ischemia-Reperfusion Injury Model

3 citations, December 2018 in “Biomedical and pharmacology journal/Biomedical & pharmacology journal”

Compound 3 protects the heart from damage by activating A1-adenosine receptors.

research Inhibition of SARS-CoV-2 Entry Through the ACE2/TMPRSS2 Pathway: A Promising Approach for Uncovering Early COVID-19 Drug Therapies

77 citations, July 2020 in “European Journal of Clinical Pharmacology”

Blocking the virus's entry into cells by targeting certain pathways could lead to early COVID-19 treatments.

research Phosphodiesterase (PDE) Inhibitors for the Treatment of Inflammatory Skin Conditions

January 2018 in “Springer eBooks”

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.

research Phosphodiesterase Inhibitors and Prostaglandin Analogues in Dermatology: A Comprehensive Review

9 citations, December 2020 in “Dermatologic Therapy”

Certain drugs are effective for skin conditions like psoriasis, vitiligo, and hair loss.

View more "phosphodiesterase iii inhibitor" in research →

Community Join

0 / 0 results

— no results