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Did you mean Nonsteroidal Antiandrogens?

Glossary Nonsteroidal Antiandrogens

medications that block male hormones without activating their receptors

Nonsteroidal Antiandrogens (NSAA) are medications that block the action of androgens (male hormones like testosterone) by binding to androgen receptors without activating them. They are commonly used in the treatment of conditions like prostate cancer and androgenic alopecia (hair loss) by preventing androgens from stimulating the growth of cancer cells or hair follicles.

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Research

5 / 1000+ results

research Discovery of Nonsteroidal Androgens

209 citations , March 1998 in “Biochemical and biophysical research communications”

This study identified a novel class of nonsteroidal ligands that can mimic the effects of dihydrotestosterone on androgen receptors, suggesting potential therapeutic applications in male fertility and hormone replacement therapy.

research Nonsteroidal tissue selective androgen receptor modulators: a promising class of clinical candidates

38 citations , October 2005 in “Expert opinion on therapeutic patents”

This review discusses nonsteroidal selective androgen receptor modulators and their potential therapeutic applications but reports no new clinical findings.

research Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

23 citations , October 2008 in “Journal of medicinal chemistry”

This study suggests that PF-0998425 is an effective androgen receptor antagonist for sebum control and androgenetic alopecia with rapid metabolism reducing the risk of systemic side effects.

research Development of radioiodinated nonsteroidal androgen receptor ligands for spect imaging of prostate cancer

1 citations , May 2001 in “Journal of Labelled Compounds and Radiopharmaceuticals”

Scientists at the University of Michigan Medical School successfully created a special compound that can be used to improve imaging of prostate cancer.

research Nonsteroidal Selective Androgen Receptors Modulators (SARMs): Designer Androgens with Flexible Structures Provide Clinical Promise

28 citations , November 2004 in “Endocrinology”

This study by Gao et al. reports that two nonsteroidal selective androgen receptor modulators, S1 and S4, demonstrated tissue-selective actions in rats, suppressing prostate growth while maintaining muscle growth without altering hormone levels.

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Learn

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learn Bicalutamide

a nonsteroidal anti-androgen, most commonly used orally for women

learn Fluridil

a topical anti-androgen with less systemic involvement

learn Pyrilutamide

highly targeted anti-androgen that might have minimal systemic effects

learn Overview

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

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Community Join

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community Has anyone find a way to stop/limit ru58841 to go systematic ?

in Finasteride/Dutasteride 4 upvotes 1 year ago

RU58841 is a strong non-steroidal antiandrogen for hair loss but may cause cardiovascular issues in some users. Alternatives like Pyrilutamide and Breezula are suggested due to better safety profiles and lower systemic risks.

community Which 2026 hair‑loss treatments have the strongest evidence so far? (minoxidil/finasteride vs. clascoterone, PP405, Re:You’s NV‑623/624, AMP‑303, RU58841)

44 upvotes 2 months ago

Minoxidil and finasteride are the only FDA-approved treatments for androgenetic alopecia, while newer treatments like clascoterone, PP405, NV-623/624, AMP-303, and RU58841 are still experimental with varying levels of evidence. Clascoterone shows the most promise due to strong human data, while AMP-303 has notable early human trial results; RU58841 lacks human data and remains experimental.

community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 194 upvotes 1 year ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

community Is this broscience? From More Plates, More Dates

in Research/Science 21 upvotes 2 years ago

The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

community Where do you guys get Topilutamide from? (if you even do)

in Chat 5 upvotes 4 months ago

The conversation discusses sourcing Topilutamide (fluridil) as a treatment for hair loss, with users comparing it to RU58841 and finasteride. Users share their experiences with various treatments, including testosterone, DHT gel, and Proviron, while expressing difficulty in finding Topilutamide.

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