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research Heterozygous KRT32 variant is responsible for autosomal dominant loose anagen hair syndrome

May 2025

In this study, researchers identified the c.296C>T (p.T99I) variant in the KRT32 gene, which co-segregates with loose anagen hair syndrome, and found it decreases binding affinity to KRT82, potentially weakening hair anchorage.

research Non-Neoplastic Disorders of Hair

January 2010 in “Elsevier eBooks”

The document concludes that different types of hair loss have specific treatments, and early diagnosis is crucial for preventing permanent hair loss.

research 1311 Efficacy of topical tofacitinib in promoting hair growth in non-scarring alopecia

April 2018 in “Journal of Investigative Dermatology”

In this study, topical tofacitinib significantly promoted hair regrowth in mice, outpacing both minoxidil and controls over 21 days, with findings suggesting increased VEGF levels and decreased inflammation as possible mechanisms.

research Summary of Hair Diseases: Cicatricial and Non-Cicatricial

March 2021 in “CRC Press eBooks”

This review discusses the characteristics and diagnostic methods of androgenetic alopecia and reports no new clinical results; it highlights trichoscopy as a key tool, replacing scalp biopsies.

research Efficacy of topical tofacitinib in promoting hair growth in non-scarring alopecia: possible mechanism via VEGF induction

27 citations , September 2017 in “Archives of Dermatological Research”

In this study, topical tofacitinib significantly increased hair regrowth in mice compared to minoxidil or vehicle, potentially due to elevated VEGF levels and reduced inflammation.

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community I thought I was a non-responder to minoxidil when it was actually saving my hair

in Minoxidil 62 upvotes 2 years ago

The user started losing hair at 20 and began using minoxidil. After seeing further hair loss, they switched to finasteride, causing more hair shedding. They are now using minoxidil, finasteride (topical and oral), microneedling, and ketoconazole shampoo for recovery.

community Ultrasound can show you if your hair will ever grow back

in Research/Science 41 upvotes 5 months ago

Ultrasound imaging can non-invasively detect active and inactive hair follicles, inflammation, and fibrosis, potentially reducing unnecessary biopsies. It may help assess hair growth potential and diagnose scalp issues, but some users believe in trying treatments regardless of ultrasound results.

community Best scalp serums while on minoxidil and can they contain caffeine?

6 upvotes 11 months ago

The user is using oral finasteride and minoxidil 2mg for hair loss and is considering adding a scalp serum with caffeine, but is concerned it might interfere with minoxidil. They seek advice on maintaining a hydrated, non-oily scalp.

community Quote from Pelage (PP-405) Spokesperson...

122 upvotes 11 months ago

Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

community Redensyl for Hair Loss — What It Can and Can’t Do

9 months ago

Redensyl is a plant-based treatment that may support hair regrowth by reactivating dormant follicles and improving hair density, especially in early-stage thinning. It is not a miracle cure and results vary; it is less proven than Minoxidil or Finasteride and may cause scalp irritation.

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Learn

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learn Caffeine

Does caffeine stimulate hair growth or only slow hair loss? Caffeine stimulates hair follicles in laboratory cultures, and one open-label trial in 210 men found a 0.2% caffeine topical non-inferior to minoxidil 5% on an anagen-ratio endpoint; there is no placebo-controlled evidence that it regrows hair, and none at all in alopecia areata or telogen effluvium.

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Exosomes

Microscopic delivery system that sends growth-promoting signals to hair follicles

learn Low Level Laser Therapy

laser therapy for anti-inflammatory and likely insignificant hair regrowth effects

learn Overview

learn Beta Polypeptide

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Clinics

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Experts

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