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GlossaryNF-κB

protein complex regulating immune response and inflammation

NF-κB, or Nuclear Factor kappa-light-chain-enhancer of activated B cells, is a protein complex that plays a crucial role in regulating the immune response to infection. It acts as a transcription factor, meaning it helps control the expression of specific genes involved in inflammation, immune response, cell growth, and survival. Dysregulation of NF-κB has been linked to various conditions, including cancer, inflammatory diseases, and autoimmune disorders.

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diabetes drug with anti-inflammatory, immunomodulatory, and insulin-sensitizing properties

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research Myocardial NF-κB activation is essential for zebrafish heart regeneration

85 citations , October 2015 in “Proceedings of the National Academy of Sciences of the United States of America”

NF-κB is crucial for zebrafish heart repair, affecting heart cell growth and repair processes.

research Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

76 citations , May 2011 in “Cell death and differentiation”

A20 protein is crucial for normal skin and hair development.

research NF-κB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in the Various Pelage Hair Follicle Types

23 citations , February 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

NF-κB is crucial for different stages and types of hair growth in mice.

Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles

research Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles

22 citations , March 2017 in “Scientific reports”

Double-stranded RNA causes inflammation in hair follicle cells, which may help understand and treat alopecia areata.

research Transcriptional activation of a subset of hair keratin genes by the NF-κB effector p65/RelA

7 citations , June 2008 in “Differentiation”

The NF-κB effector p65/RelA activates hair keratin genes, aiding hair formation.

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community Got a microscope camera. Here’s the difference between healthy and miniaturized hair

in Progress Pictures 492 upvotes 2 years ago

A user who shared progress pictures of their scalp using a microscope camera, demonstrating the difference between healthy and miniaturized hair. Various explanations for the cause of this were discussed, such as DHT build-up in scalp sebum causing an autoimmune response leading to inflammation and eventual hair loss, with some suggesting a do-it-yourself treatment involving adding ascorbic acid powder to shampoo.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 448 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community Topical Finasteride update by H&W

in Finasteride 28 upvotes 6 years ago

The conversation discusses using topical finasteride for hair loss, with concerns about its safety around family members, especially pregnant women and infants. One user plans to try topical finasteride due to side effects from the pill.