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Glossary p75 neurotrophin receptor

protein on cell surfaces regulating survival and apoptosis

The p75 neurotrophin receptor (p75NTR) is a protein found on the surface of certain cells, including neurons and hair follicle cells. It plays a crucial role in regulating cell survival, growth, and apoptosis (programmed cell death) by binding to neurotrophins, which are a family of proteins that promote the survival and function of neurons. This receptor is significant in both the development of the nervous system and in conditions like alopecia, where it can influence hair follicle health and regeneration.

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research Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR.

122 citations , June 1998 in “PubMed”

This study found that sensory and sympathetic innervation in the mystacial pads of mice is governed by a balance of neurotrophin signaling, highlighting the roles of NGF/trkA and NT-3/trkC pathways.

research Inhibitory Effects of Polyacetylene Compounds from Panax ginseng on Neurotrophin Receptor-Mediated Hair Growth

October 2017 in “Institutional Repositories DataBase (IRDB)”

Polyacetylene compounds from Panax ginseng may slow hair growth.

research A role for p75 neurotrophin receptor in the control of apoptosis‐driven hair follicle regression

96 citations , October 2000 in “The FASEB Journal”

In this study, researchers found that p75 neurotrophin receptor signaling affects apoptosis during hair follicle regression in mice, and altering its activity might help manage disorders involving early catagen entry.

research p75 Neurotrophin Receptor Antagonist Retards Apoptosis-driven Hair Follicle Involution (Catagen)

24 citations , January 2003 in “Journal of Investigative Dermatology”

In this study, a synthetic antagonist of the p75 neurotrophin receptor was found to significantly inhibit hair follicle regression in murine skin cultures, suggesting a potential role in treating hair disorders characterized by premature catagen entry.

research Retardation of Hair Follicle Development by the Deletion of TrkC, High-Affinity Neurotrophin-3 Receptor

14 citations , September 1999 in “Journal of Investigative Dermatology”

Lack of TrkC receptor delays hair follicle development.

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community My husband has experienced depression and suicidal thoughts from finasteride

32 upvotes 1 month ago

Finasteride caused depression and suicidal thoughts in OP's husband, leading him to stop the medication. He is seeing a doctor for a full hormone panel and psychiatric referral to address these issues.

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