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Glossary Neurodegenerative Disease

progressive loss of neuron function or structure

A Neurodegenerative Disease is a condition characterized by the progressive loss of structure or function of neurons, including their death. Common examples include Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). These diseases often lead to cognitive decline, motor dysfunction, and other neurological impairments, significantly impacting quality of life.

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research Phytomedicine for neurodegenerative diseases: The road ahead

18 citations , April 2024 in “Phytotherapy Research”

This review examines the potential of plant-derived compounds like quercetin, curcumin, EGCG, apigenin, and cannabinoids for treating neurodegenerative disorders, while discussing their benefits and limitations, and calls for more extensive pre-clinical and clinical research.

research Do Dermatoses Trigger Neurodegenerative Diseases? A Retrospective Observational Study

September 2025 in “Dicle Medical Journal / Dicle Tip Dergisi”

In this retrospective study, researchers found that fungal infections, xerosis, eczematous dermatitis, and seborrheic dermatitis were the most common dermatological findings among patients with Parkinson's disease, Multiple Sclerosis, and Amyotrophic Lateral Sclerosis, with significant intergroup differences observed.

research Unraveling the complex role of MAPT-containing H1 and H2 haplotypes in neurodegenerative diseases

26 citations , May 2024 in “Molecular Neurodegeneration”

This review assesses existing knowledge about the 17q21.31 inversion polymorphism, highlighting its genetic structure differences across ancestries, associations with various diseases, and implications for precision medicine and drug discovery.

research Long-lived proteins and DNA as candidate predictive biomarkers for tissue associated diseases

3 citations , March 2024 in “iScience”

This study found that long-lived proteins in mice, identified across various tissues, may be linked to neurodegenerative and cardiovascular diseases due to their low renewal rate and increased risk of damage.

research Susan Lee Lindquist (1949–2016)—pioneer in the study of cellular protein folding and disease

2 citations , December 2016 in “EMBO journal”

This obituary honors Susan Lee Lindquist for her pioneering work in cellular protein folding and genetics, highlighting her significant contributions to science and mentorship in her nearly 40-year career.

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community Dutasteride absolutely nukes hair DHT

in Finasteride/Dutasteride 486 upvotes 1 year ago

Dutasteride significantly reduces DHT levels, potentially more effectively than finasteride, and is used to treat hair loss. Some users report side effects like reduced libido and mood changes, while others experience hair regrowth and increased testosterone.

community If PP405 goes systemic this would be quite catastrophic

in Research/Science 4 upvotes 1 year ago

Concerns about the potential systemic effects and safety of PP405 for hair loss, with discussions on its comparison to existing treatments like finasteride and minoxidil. Users express skepticism about untested research chemicals and emphasize the importance of clinical trials to ensure safety and efficacy.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 2 years ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

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