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GlossaryNeurodegenerative Disease

progressive loss of neuron function or structure

A Neurodegenerative Disease is a condition characterized by the progressive loss of structure or function of neurons, including their death. Common examples include Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). These diseases often lead to cognitive decline, motor dysfunction, and other neurological impairments, significantly impacting quality of life.

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research Teriflunomide Efficacy, Safety, and Tolerability in Patients with Relapsing Forms of Multiple Sclerosis

September 2013 in “Neurodegenerative disease management”

Teriflunomide is effective and generally safe for treating relapsing multiple sclerosis, reducing relapse rates and disability progression.

Antioxidants and Mitochondrial Bioenergetics: Charnoly Bodies in Neurodegenerative Diseases, Cardiovascular Disorders, and Cancer

research Antioxidants and Mitochondrial Bioenergetics: Charnoly Bodies in Neurodegenerative Diseases, Cardiovascular Disorders, and Cancer

January 2017 in “Elsevier eBooks”

Antioxidants may help improve mitochondrial health and could be used to treat diseases related to cell damage.

research Teriflunomide in Multiple Sclerosis: An Update

20 citations , December 2016 in “Neurodegenerative disease management”

Teriflunomide effectively reduces relapses and disability in MS and has a manageable safety profile.

research CAG Repeat Testing of Androgen Receptor Polymorphism: Is This Necessary for the Best Clinical Management of Hypogonadism?

29 citations , July 2013 in “The Journal of Sexual Medicine”

Testing for CAG repeat polymorphism in the androgen receptor gene is not currently recommended for managing hypogonadism.

research Susan Lee Lindquist (1949–2016)—Pioneer in the Study of Cellular Protein Folding and Disease

2 citations , December 2016 in “EMBO journal”

Susan Lee Lindquist was a pioneering biologist who made significant contributions to understanding protein folding and its role in disease.

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community Dutasteride absolutely nukes hair DHT

in Finasteride/Dutasteride 486 upvotes 9 months ago

Dutasteride significantly reduces DHT levels, potentially more effectively than finasteride, and is used to treat hair loss. Some users report side effects like reduced libido and mood changes, while others experience hair regrowth and increased testosterone.

community If PP405 goes systemic this would be quite catastrophic

in Research/Science 4 upvotes 1 year ago

Concerns about the potential systemic effects and safety of PP405 for hair loss, with discussions on its comparison to existing treatments like finasteride and minoxidil. Users express skepticism about untested research chemicals and emphasize the importance of clinical trials to ensure safety and efficacy.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 1 year ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community I find it crazy how some people like this bloke have 0 DHT sensitivity. He is on grams of anabolic steroids and has a full, thick head of hair. I wish all of on here had this guys hair genes lol

in Satire 443 upvotes 2 years ago

The conversation is about hair loss and the possibility of maintaining a full head of hair while using anabolic steroids. Some users believe that having good hair genes and taking hair loss protocols can help prevent hair loss while on steroids.

community Anybody on here from Germany who can talk to us about alfatradiol (Avicis, Avixis, Ell-Cranell Alpha and Pantostin)? Availability, public perception, etc?

in Treatment 6 upvotes 4 years ago

Hair loss treatments discussed include Minoxidil, Finasteride, and RU58841. A user asks about alfatradiol's availability, public perception, and usage in Germany.

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