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Neurosteroids

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Physiopathological Role of the Enzymatic Complex 5α-Reductase and 3α/β-Hydroxysteroid Oxidoreductase in the Generation of Progesterone and Testosterone Neuroactive Metabolites

research Physiopathological Role of the Enzymatic Complex 5α-Reductase and 3α/β-Hydroxysteroid Oxidoreductase in the Generation of Progesterone and Testosterone Neuroactive Metabolites

18 citations , March 2020 in “Frontiers in Neuroendocrinology”

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

research Divergent Neuroactive Steroid Responses to Stress and Ethanol in Rat and Mouse Strains: Relevance for Human Studies

34 citations , April 2014 in “Psychopharmacology”

Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.

Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

research Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

123 citations , December 2015 in “Journal of Neuroendocrinology”

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

research Exploring the Impact of the Microbiome on Neuroactive Steroid Levels in Germ-Free Animals

11 citations , November 2021 in “International journal of molecular sciences”

Gut microbes significantly affect brain steroid levels.

research Effects of Non-Contingent Cocaine on 3alpha-Androstanediol: Disruption of Male Sexual Behavior

4 citations , May 2019 in “Physiology & Behavior”

Cocaine impairs male sexual behavior and alters testosterone metabolism in the brain.

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community Finasteride and “anti-aging” effects

in Treatment 211 upvotes 4 days ago

Finasteride may help users look younger by suppressing DHT, affecting skin and hair. Users also emphasize skincare, sunscreen, and lifestyle for maintaining a youthful appearance.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 1 year ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community Why is Kevin Mann (Haircafe) Hated?

in Chat 62 upvotes 2 years ago

Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

community risks with finasteride and dutasteride

in Research/Science 141 upvotes 2 months ago

Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

community The safest way to use finasteride - my research

in Finasteride 23 upvotes 8 years ago

The post discusses microdosing finasteride to minimize side effects while treating hair loss. The user also mentions using minoxidil, biotin, and ketoconazole.

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