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research Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene

139 citations, September 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mutations in the Vitamin D receptor gene can cause hair loss similar to mutations in the Hairless gene.

Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

research Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

181 citations, January 2009 in “Nature Genetics”

Certain mutations in a hair growth-related gene cause a type of genetic hair loss.

research Molecular and Functional Aspects of the Hairless (Hr) Gene in Laboratory Rodents and Humans

126 citations, October 1998 in “Experimental Dermatology”

The hr gene is crucial for skin and hair health, with mutations causing hair disorders.

research Disease Causing Homozygous Variants in the Human Hairless Gene

7 citations, December 2015 in “International Journal of Dermatology”

New and known mutations in the hairless gene cause a hair loss condition called Atrichia with papular lesions.

research Intragenic Deletion in the Desmoglein 4 Gene Underlies the Skin Phenotype in the Iffa Credo Hairless Rat

28 citations, October 2004 in “Differentiation”

A gene deletion causes the "hairless" trait in Iffa Credo rats.

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community People need to start accepting that only medical therapy (Fin/Dut) can save your hair in the long run.

in Treatment 112 upvotes 11 months ago

Minoxidil can regrow hair but doesn't address the underlying issue of DHT, leading to continued hair loss. Users discuss their experiences with finasteride and dutasteride, mentioning side effects, personal outcomes, and alternatives like microdosing topical finasteride.

community One and a half year on meds (fin/dut, minox)

in Progress Pictures 54 upvotes 2 months ago

The user has been using oral minoxidil, finasteride, and dutasteride to prevent hair loss, despite not showing significant balding. Many commenters believe the treatment is excessive, while some support early prevention.

community Can a folate deficiency make androgenetic alopecia worse?

in Treatment 1 upvotes 11 months ago

The user is treating androgenetic alopecia with finasteride and discovered a folic acid deficiency. They are asking if curing the deficiency can worsen or improve their hair condition.

community I believe CRISPR-on & CRISPR-off is an ultimate CURE for baldness, unlike Hair Cloning or hair loss treatments.

in Research/Science 22 upvotes 3 years ago

The conversation discusses CRISPR-on & CRISPR-off as a potential cure for baldness, contrasting it with hair cloning and other treatments like Minoxidil, finasteride, and RU58841. It also mentions the potential of mRNA for gene expression control and the prioritization of gene editing for severe genetic conditions.

community How promising is th RCH-01/Replicel treatment? Is there any new info that suggests it will be as successful as it claims? What other promising treatments are close?

in Technology 14 upvotes 5 years ago

The conversation is about the potential of the RCH-01/Replicel hair loss treatment and its lack of updates since 2013, with the user expressing hope for its success and considering using Minoxidil, finasteride, and dermarolling in the meantime. Other treatments mentioned as promising are Breezula and Tsuji.

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