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      learn Osteopontin

      signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

      learn SCUBE3

      a signaling molecule from dermal papilla cells being actively researched

      learn KY19382

      compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

      learn PP405

      mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

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      community Hair Loss Treatment Iceberg Chart

      in Satire  1379 upvotes 3 years ago
      Hair loss treatments discussed include Minoxidil, Finasteride, RU58841, ass hair transplant, topical Viagra, castration, and transitioning to female. A user mentions an experimental drug called M4U-5 (Mousteride) that turns you into a mouse.

      community Is anyone buying this comb over?

      in Styling  310 upvotes 2 years ago
      User has diffuse thinning crown and uses combover with hair spray. Oral minoxidil showed amazing results for another user.

      community PP405 Phase 2a press release with early results

      in Research/Science  691 upvotes 2 weeks ago
      PP405 shows promise in hair regrowth, with 31% of participants experiencing over 20% increase in hair density after 8 weeks. Phase 3 trials are expected in 2026, with potential market availability by 2029-2031.

      community The Cure isn't 5 years away; it's already here.

      in Research/Science  1005 upvotes 6 months ago
      PP405 is a new topical treatment for hair loss, showing promise in trials but still requires finasteride for maintenance. There is skepticism about its effectiveness and safety, with concerns about needing finasteride to maintain results.