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community Hair Multiplication Projects in China - Promising clinical trial results on Mice

34 upvotes 1 year ago

A breakthrough in hair follicle cultivation using induced pluripotent stem cells (iPSCs) has been achieved, producing large hair follicles suitable for transplantation. Clinical trials for this hair multiplication technology are planned in partnership with Yinguan Biotechnology.

community Han Bio Aims for Phase 1 Clinical Trials in 2027 after successful hair growth in mice

in Research/Science 248 upvotes 1 year ago

Han Bio plans to start Phase 1 clinical trials for a hair growth treatment in 2027 after successful results in mice. Many users express skepticism about the effectiveness of treatments that work on mice but not on humans, and discuss existing treatments like finasteride and minoxidil.

community OrganTech Aims to Regenerate Hair and Teeth, trial on Mice show positive results

86 upvotes 1 year ago

OrganTech is working on regenerating hair and teeth, with positive results in mice, but skepticism remains about progress for humans. Users express frustration over the lack of advancements in human hair loss treatments, despite ongoing research and trials.

community Now that hair loss in mice is solved, can they move on to people?

709 upvotes 6 months ago

Hair loss treatments are being tested on mice, with methods like minoxidil and stem cell therapy showing promising results. However, human trials are still years away, leading to humorous frustration about mice benefiting first.

community Innovative hair loss treatment can restore 90% of lost hair

890 upvotes 2 years ago

A new hair loss treatment using dermal exosomes can restore up to 90% of lost hair in mice. Users discuss potential human trials and compare it to Minoxidil and Finasteride.

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Research

5 / 1000+ results

research IL-12/IL-23 neutralization is ineffective for alopecia areata in mice and humans

20 citations , December 2019 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

In this study, ustekinumab did not promote hair regrowth in human patients with alopecia areata or prevent disease development in an AA mouse model, suggesting limited efficacy for this treatment.

research The Preclinical and Clinical Effects of Herbal Product Containing Rosa mutiflora Roots Extracts as a Main Component on the Hair Growth Promotion

8 citations , April 2012 in “Korean journal of medicinal crop science/Han-gug yagyong jagmul hag-hoeji”

This study found that the herbal product containing Rosa multiflora roots extract improved hair density and thickness and significantly promoted hair growth in both mice and human patients after 16 weeks of treatment.

research 614 Humanized mouse model for hair follicle studies

September 2019 in “Journal of Investigative Dermatology”

This study established a model using nude mice to successfully graft human scalp skin, maintaining hair follicle growth and skin integrity for at least two months, which may aid preclinical research.

research Assessment of Trial to Use Exosomes and Salmon DNA with Minoxidil as Multisource Mixture for Hair Follicle Activation an In Vivo Study

March 2025 in “Benha Journal of Applied Sciences”

In this study using C57BL/6 mice, the researchers observed that combining minoxidil with exosomes and DNA polynucleotides improved hair follicle density and promoted gene expression linked to hair growth, suggesting enhanced hair growth potential over minoxidil alone.

research Alterations in transcriptome and antioxidant activity of naturally aged mice exposed to selenium-rich rice

10 citations , April 2019 in “Environmental Science and Pollution Research”

In this study, selenium-rich diets enhanced antioxidant activity in aged mice, suggesting potential biological benefits, although further trials are needed to fully understand long-term risks and benefits.

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Learn

9 / 19 results

learn Rosemary

Is rosemary oil a real treatment or just a supplement? One small trial compared rosemary oil with 2% minoxidil but had no placebo arm; the rest of the evidence comes from mice and lab work. Rosemary oil is not an established hair-loss treatment.

learn Ecklonia Cava

Is Ecklonia Cava better taken orally or applied topically for thinning hair? There is no human trial of Ecklonia cava for hair loss by either route, so neither oral nor topical use is established; the published work is laboratory studies on human cells and topical studies in mice.

learn Vascular Endothelial Growth Factor

Are there risks or side effects associated with treatments that increase Vascular Endothelial Growth Factor (VEGF)? In a VEGF gene-therapy trial for leg artery disease, raising VEGF caused more leg swelling, and excess VEGF drives leaky, abnormal vessels in mice and in eye disease. No long-term studies have tested the safety of treatments that raise VEGF in the scalp.

learn SCUBE3

How does SCUBE3 work on hair follicles compared to treatments like minoxidil or finasteride? Laboratory research in mice reports that SCUBE3, a protein released by dermal papilla cells, signals dormant follicles to grow through the TGF-β pathway downstream of Hedgehog; minoxidil and finasteride instead work on blood flow to the follicle and on DHT, and unlike SCUBE3 they have decades of human trial data behind them. SCUBE3 has not been tested in human clinical trials and is not available as a medicine.

learn Lavender

Plant essential oil used in scalp products

Does lavender promote hair growth or just soothe an irritated scalp? A 2016 study found more hair growth in mice treated with lavender oil, but no trial has tested lavender alone for hair loss in people. Lavender oil can cause skin allergy, and case reports link lavender products to breast growth in children.

learn PP405

mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

learn Low Level Laser Therapy

Red-light devices, such as caps, combs and helmets, used on the scalp

learn RU58841

Experimental topical anti-androgen sold as a research chemical

learn Rapamycin

Immune-suppressing drug, also called sirolimus

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