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GlossaryMerkel cells

specialized skin cells that detect touch and pressure

Merkel cells are specialized skin cells located in the epidermis, particularly in areas with high tactile sensitivity like fingertips. They function as mechanoreceptors, meaning they help detect touch and pressure, and are connected to nerve endings to transmit sensory information to the brain.

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research Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection

133 citations , May 2016 in “Cell Host & Microbe”

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

research Dynamics of Merkel Cell Patterns in Developing Hair Follicles in the Dorsal Skin of Mice, Demonstrated by a Monoclonal Antibody to Mouse Keratin 8

64 citations , January 1995 in “Cells Tissues Organs”

Merkel cells develop independently of nerves and are linked to specific hair follicles in mice.

research Ectopic Atoh1 Expression Drives Merkel Cell Production in Embryonic, Postnatal, and Adult Epidermis

41 citations , January 2015 in “Development”

Atoh1 expression can create new Merkel cells in the skin.

research Merkel cell differentiation in trichoblastoma

34 citations , January 1998 in “Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin”

research The Cellular Basis of Mechanosensory Merkel-Cell Innervation During Development

32 citations , February 2019 in “eLife”

BMP signaling is essential for the development of touch domes.

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