48 citations
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April 2021 in “Pharmaceuticals” The study evaluated the efficacy of curcumin-loaded liposomes in photodynamic therapy (PDT) on melanoma (MUG-Mel2), squamous cell carcinoma (SCC-25), and normal keratinocyte (HaCaT) cells. It demonstrated that liposomal curcumin significantly enhanced phototoxicity and apoptosis in cancer cells compared to free curcumin, with a 53% reduction in MUG-Mel2 and 58% in SCC-25 cell viability. The treatment also inhibited cancer cell migration, suggesting potential in preventing metastasis. Importantly, normal HaCaT cells maintained about 90% viability, indicating reduced toxicity. These findings suggested that liposomal curcumin could improve PDT effectiveness for skin cancers while minimizing harm to normal cells, warranting further in vivo testing.
1 citations
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March 2011 in “Journal of Investigative Dermatology” Blocking RANK signaling might help treat metastatic melanoma, but more research is needed.
7 citations
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January 2023 in “Journal of Hematology & Oncology” Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.
April 2024 in “Journal of translational medicine” Melanocytes are important for normal body functions and have potential uses in regenerative medicine and disease treatment.
14 citations
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June 2018 in “Frontiers in pharmacology” Green tea compound EGCG helps mink hair follicles grow by affecting certain cell growth pathways.