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natural substance from Neem tree with medicinal and pesticidal properties
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Research
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research A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth
Certain immune cells in the skin release a protein that stops hair growth by keeping hair stem cells inactive.
research Research Progress in Chronic Autoimmune Urticaria
The document discussed chronic autoimmune urticaria (CAU), a subtype of chronic spontaneous urticaria characterized by histamine-releasing IgG autoantibodies. It highlighted the role of the oncostatin M receptor (OSMR) gene in CAU pathogenesis, where silencing the OSMR gene reduced inflammation by inhibiting the JAK/STAT3 signaling pathway. Psychological stress was found to exacerbate CAU by affecting the HPA axis and increasing pro-inflammatory cytokines like IL-6 and IL-18. Diagnosis involved bioassays and immunoassays for specific autoantibodies. Omalizumab, an anti-IgE therapy, was effective for antihistamine-resistant CAU by reducing IgE levels and mast cell activation. The document emphasized the need for immunosuppressive agents, such as low-dose cyclosporine, azathioprine, and sulfasalazine, due to CAU's autoimmune nature. Cyclosporine had T-cell-mediated action but potential side effects, azathioprine showed lasting symptom suppression, and sulfasalazine was safe but required careful monitoring. Improved diagnostic methods and treatment optimization were needed due to CAU's complexity.
research Main Plenary Sessions: Summaries of Papers
UK medical students lack dermatology education, liver biopsy patients with risk factors show more fibrosis, and certain fungi resist drugs due to melanin; genetics may influence female hair loss.
research In Silico Modelling of Transdermal Delivery of Macromolecule Drugs Assisted by a Skin Stretching Hypobaric Device
The simulation showed that hypobaric pressure improves drug delivery through the skin, but stretching alone doesn't fully explain the increase.
research Unmet Medical Needs in Chronic, Non-Communicable Inflammatory Skin Diseases
There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.
Community Join
5 / 1000+ resultscommunity Shedding and thinning won’t stop on Nuclear protocol
The user is using a combination of hair loss treatments including dutasteride, minoxidil, RU58841, low-level laser therapy, ketokonozole, supplements, Viviscal, Nutrafol, microneedling, PRP, and scalp Botox injections, but is still experiencing hair shedding and thinning. Despite being on this regimen for two years, the user's hair condition is worsening, and they are seeking advice on what else they can do.
community Having androgen receptor density and sensitivity at wrong f*ing place
The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.
community Oral Minoxidil & Coffee – Any issues due to adenosine receptor blockade?
Oral Minoxidil users discuss whether caffeine affects its effectiveness due to adenosine receptor blockade. Users report no significant impact on hair growth despite caffeine consumption.
community Is regrowth on an androgen receptor blocker possible?
RU and Pyri block androgen receptors to prevent hair loss but may also hinder hair regrowth since they prevent testosterone, which can stimulate hair growth, from binding to these receptors. The user is questioning if this understanding is correct.
community [29 M] 7 month pyrilutamide update.
A 29-year-old male experienced hair regrowth using minoxidil 5% foam and KX826 after stopping finasteride due to side effects. He applies both treatments once daily and reports no side effects from the current regimen.