Research Progress in Chronic Autoimmune Urticaria

    November 2019 in “ International Journal of Dermatology and Venereology ”
    Shan Zhang, Xu Yao, Xueyuan Yang
    TLDR Chronic autoimmune urticaria can be managed with specific therapies and requires improved diagnosis and treatment methods.
    The document discussed chronic autoimmune urticaria (CAU), focusing on its pathogenesis, diagnosis, and treatment. It highlighted the role of the oncostatin M receptor (OSMR) gene in CAU, where gene silencing reduced inflammation by inhibiting the JAK/STAT3 pathway. Psychological stress was found to exacerbate CAU through the HPA axis, increasing pro-inflammatory cytokines. Diagnosis relied on bioassays and immunoassays. Omalizumab was effective for antihistamine-resistant CAU by reducing IgE levels. Treatment with immunosuppressive agents like cyclosporine, azathioprine, and sulfasalazine was discussed, noting cyclosporine's side effects and azathioprine's lasting symptom suppression. The document emphasized the need for better diagnostic methods and treatment optimization due to CAU's complexity.
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