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GlossaryGonadotropin-Releasing Hormone Antagonists (GnRH antagonists)

medications that block hormone signals to reduce sex hormone production

Gonadotropin-Releasing Hormone Antagonists (GnRH antagonists) are medications that block the action of GnRH, a hormone responsible for stimulating the release of other hormones like LH and FSH from the pituitary gland. By inhibiting this pathway, GnRH antagonists can reduce the production of sex hormones such as testosterone and estrogen, making them useful in treatments for conditions like prostate cancer, endometriosis, and certain fertility issues.

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research Recent Discoveries and Developments of Androgen Receptor-Based Therapy for Prostate Cancer

17 citations, January 2015 in “MedChemComm”

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

research Androgen Antagonists in Androgen Target Tissues

27 citations, January 1984 in “Pharmacology & Therapeutics”

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

research Treatment of Androgen Excess in Females: Yesterday, Today, and Tomorrow

9 citations, January 1997 in “Gynecological Endocrinology”

The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.

research Hormonal Manipulation of Benign Prostatic Hyperplasia

18 citations, November 2012 in “Current opinion in urology”

Finasteride and dutasteride are equally effective and safe for treating benign prostatic hyperplasia.

research The Dihydrotestosterone Hypothesis of Prostate Cancer and Its Therapeutic Implications

57 citations, January 1986 in “The Prostate”

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

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community Why haven’t we seen anything about this

in Research/Science 18 upvotes 4 years ago

A double blind, placebo-controlled study that looked into the potential effectiveness of topical fluridil for treating male androgenetic alopecia, showing increased anagen to telogen ratios with no reported side effects on libido or sexual performance.

community Bloodwork after 8 months on finasteride, is this normal?

in Update 27 upvotes 8 months ago

A user on finasteride for 8 months shared bloodwork results showing increased testosterone and estradiol levels, with concerns about high LH. Responses advised monitoring for symptoms but noted levels are within reference ranges.

community How’s my pre fin lab work. Age 40

in Chat 6 upvotes 6 months ago

A user shared their pre-finasteride lab results, including DHT, estradiol, testosterone, SHBG, prolactin, FSH, and LH levels. Another user responded, cautioning against making unsupported claims about side effects and recovery.

community Which labs / blood baseline markers to check before beginning treatment?

in Finasteride/Dutasteride 6 upvotes 3 years ago

The conversation is about which blood tests are essential to check before starting hair loss treatment with finasteride or dutasteride. The tests mentioned include DHT, PSA, Estrogen/Estradiol, Testosterone, FSH, and LH.

community Bloodwork before fin/dut impact on progesterone level

in Finasteride/Dutasteride 10 upvotes 8 months ago

A 26-year-old man who had a hair transplant and used minoxidil with good results is now experiencing shedding and considering finasteride. He's concerned about high progesterone and mild erectile dysfunction before starting the treatment.

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